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| | 5,6-Bis[(4-fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione Basic information |
| Product Name: | 5,6-Bis[(4-fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione | | Synonyms: | CGP 53353;5,6-BIS[(4-FLUOROPHENYL)AMINO]-2H-ISOINDOLE-1,3-DIONE;5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione, DAPH 2;DAPH 2;DAPH-7;PKCβII/EGFR Inhibitor - CAS 145915-60-2 - Calbiochem;1H-Isoindole-1,3(2H)-dione, 5,6-bis[(4-fluorophenyl)amino]-;CGP-53353 solid | | CAS: | 145915-60-2 | | MF: | C20H13F2N3O2 | | MW: | 365.33 | | EINECS: | | | Product Categories: | Protein Kinase | | Mol File: | 145915-60-2.mol | ![5,6-Bis[(4-fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione Structure](CAS/GIF/145915-60-2.gif) |
| | 5,6-Bis[(4-fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: >10mg/mL | | form | solid | | color | orange | | InChI | 1S/C20H13F2N3O2/c21-11-1-5-13(6-2-11)23-17-9-15-16(20(27)25-19(15)26)10-18(17)24-14-7-3-12(22)4-8-14/h1-10,23-24H,(H,25,26,27) | | InChIKey | RONQPWQYDRPRGG-UHFFFAOYSA-N |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | 5,6-Bis[(4-fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione Usage And Synthesis |
| Uses | CGP 53353 inhibited tyrosine kinase activity of the EGF-R in five different human transitional cell carcinoma lines. | | Definition | ChEBI: 5,6-bis(4-fluoroanilino)isoindole-1,3-dione is a member of phthalimides. | | Biological Activity | Selective inhibitor of PKC β II (IC 50 values are 0.41 and 3.8 μ M for PKC β II and PKC β I respectively). Also inhibits prionogenic Sup35 fibrillization (IC 50 ~ 3.4 μ M) and inhibits de novo A β 42 assembly in vitro . | | IC 50 | PKCβII: 0.41 mM (IC50); PKCβI: 3.8 mM (IC50) | | storage | Store at RT |
| | 5,6-Bis[(4-fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione Preparation Products And Raw materials |
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