[6-(Diethoxy-phosphorylamino)-hexyl]-phosphoramidic acid diethyl ester

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[6-(Diethoxy-phosphorylamino)-hexyl]-phosphoramidic acid diethyl ester Basic information
Product Name:[6-(Diethoxy-phosphorylamino)-hexyl]-phosphoramidic acid diethyl ester
Synonyms:[6-(Diethoxy-phosphorylamino)-hexyl]-phosphoramidic acid diethyl ester;C6-Bis-phosphoramidic acid diethyl ester
CAS:1446282-35-4
MF:C14H34N2O6P2
MW:388.38
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Product Categories:
Mol File:1446282-35-4.mol
[6-(Diethoxy-phosphorylamino)-hexyl]-phosphoramidic acid diethyl ester Structure
[6-(Diethoxy-phosphorylamino)-hexyl]-phosphoramidic acid diethyl ester Chemical Properties
Boiling point 442.2±55.0 °C(Predicted)
density 1.106±0.06 g/cm3(Predicted)
pka2.06±0.70(Predicted)
Safety Information
MSDS Information
[6-(Diethoxy-phosphorylamino)-hexyl]-phosphoramidic acid diethyl ester Usage And Synthesis
UsesC6-Bis-phosphoramidic acid diethyl ester is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Biological ActivityC6-Bis-phosphoramidic acid diethyl ester is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
IC 50Alkyl-Chain
References[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
[6-(Diethoxy-phosphorylamino)-hexyl]-phosphoramidic acid diethyl ester Preparation Products And Raw materials
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