| Company Name: |
Sigma-Aldrich |
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
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| | ALPHA-HYDROXYALPRAZOLAM Basic information |
| | ALPHA-HYDROXYALPRAZOLAM Chemical Properties |
| Melting point | 129-134°C | | Fp | 9℃ | | storage temp. | -20°C Freezer | | solubility | methylene chloride: ~20 mg/mL, clear, colorless to faintly yellow | | form | powder | | color | white to off-white | | Major Application | clinical testing | | InChI | 1S/C17H13ClN4O/c18-12-6-7-14-13(8-12)17(11-4-2-1-3-5-11)19-9-15-20-21-16(10-23)22(14)15/h1-8,23H,9-10H2 | | InChIKey | ZURUZYHEEMDQBU-UHFFFAOYSA-N | | SMILES | OCc1nnc2CN=C(c3ccccc3)c4cc(Cl)ccc4-n12 |
| Hazard Codes | Xn,T,F | | Risk Statements | 20/21/22-39/23/24/25-23/24/25-11 | | Safety Statements | 36-45-36/37-16-7 | | RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | | WGK Germany | 3 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Flam. Liq. 2
STOT SE 1 |
| | ALPHA-HYDROXYALPRAZOLAM Usage And Synthesis |
| Description | α-hydroxy Alprazolam (Item No. 15287) is an analytical reference material categorized as a benzodiazepine. It is a major active metabolite of alprazolam (CRM) that has a higher urinary recovery than 4-hydroxy alprazolam , another major metabolite. α-hydroxy Alprazolam has a lower binding affinity than alprazolam for the GABAA receptor. It is also a metabolite of adinazolam . This product is intended for research and forensic applications. | | Chemical Properties | Yellow solid | | Uses | A metabolite of Alprazolam, an anxiolytic | | Definition | ChEBI: Alpha-Hydroxyalprazolam is a triazolobenzodiazepine. | | General Description | A major urinary metabolite of the benzodiazepine alprazolam. Alprazolam, commonly sold under the trade name Xanax, is a short-acting anxiolytic approved to treat panic and other anxiety disorders including generalized or social anxiety disorder. This certified Snap-N-Spike solution standard is suitable for use in LC/MS or GC/MS applications such as forensic analysis, clinical toxicology, urine drug testing, or pain prescription monitoring. | | References | [1] D J GREENBLATT C E W. Clinical pharmacokinetics of alprazolam. Therapeutic implications.[J]. Clinical Pharmacokinetics, 1993, 24 6: 453-471. DOI: 10.2165/00003088-199324060-00003
[2] MIOK SHIN. Screening of multiple drugs of abuse and metabolites in urine using LC/MS/MS with polarity switching electrospray ionization[J]. Archives of Pharmacal Research, 2013, 37 6: 760-772. DOI: 10.1007/s12272-013-0225-0
[3] ANNIKA ALLQVIST. Simultaneous quantification of alprazolam, 4- and α-hydroxyalprazolam in plasma samples using liquid chromatography mass spectrometry[J]. Journal of Chromatography B, 2005, 814 1: Pages 127-131. DOI: 10.1016/j.jchromb.2004.10.012
[4] A D FRASER W B A F Isner. Urinary screening for adinazolam and its major metabolites by the Emit d.a.u. and FPIA benzodiazepine assays with confirmation by HPLC.[J]. Journal of analytical toxicology, 1993, 17 7: 427-431. DOI: 10.1093/jat/17.7.427 |
| | ALPHA-HYDROXYALPRAZOLAM Preparation Products And Raw materials |
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