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BOC Sciences |
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16314854226; +8616314854226 |
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| Company Name: |
BOC Sciences |
| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
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| | (+)-ITD 1 Basic information |
| Product Name: | (+)-ITD 1 | | Synonyms: | (+)-ITD-1;3-Quinolinecarboxylic acid, 4-[1,1'-biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-, ethyl ester, (4R)- | | CAS: | 1409968-46-2 | | MF: | C27H29NO3 | | MW: | 415.52 | | EINECS: | | | Product Categories: | | | Mol File: | 1409968-46-2.mol |  |
| | (+)-ITD 1 Chemical Properties |
| Boiling point | 569.9±50.0 °C(Predicted) | | density | 1.18±0.1 g/cm3(Predicted) | | pka | 1.33±0.70(Predicted) |
| | (+)-ITD 1 Usage And Synthesis |
| Uses | (+)-ITD-1 is an inhibitor for TGF-β, that inhibits the TGF-β2 with an IC50 of 0.46 μM. (+)-ITD-1 promotes the degradation of TGF-b type II receptor (TGFBR2) and the differentiation of cardiomyocyte, and inhibits the mesoderm formation in the early differentiation stage of mouse embryonic stem cells (mESCs)[1]. | | References | [1] Willems E, et al., Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012 Aug 3;11(2):242-52. DOI:10.1016/j.stem.2012.04.025 |
| | (+)-ITD 1 Preparation Products And Raw materials |
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