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Shanghai Hongye Biotechnology Co. Ltd
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400-9205774 400-920-5774 |
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sales@glpbio.cn |
| Products Intro: |
Product Name:KMN-80
CAS:1628759-75-0
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:KMN-80
CAS:1628759-75-0
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
TargetMol Chemicals Inc.
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4008200310 15002144251 |
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marketing@tsbiochem.com |
| Products Intro: |
Product Name:KMN-80
CAS:1628759-75-0
Package:1mg/RMB 4270
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
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customer_service@efebio.com |
| Products Intro: |
Product Name:KMN-80
CAS:1628759-75-0
Purity:98% Package:500μg;1mg
|
KMN-80 manufacturers
- KMN-80
-
- $613.00
-
2026-04-22
- CAS:1628759-75-0
- Purity:
- Supply Ability: 10g
|
| Product Name: | KMN-80 | | Synonyms: | KMN-80;CBIUADIJQPJQEZ-VIDOSBHOSA-N;1-Pyrrolidineheptanoic acid, 2-[(1E,3S,4S)-3-hydroxy-4-methyl-1-nonen-6-yn-1-yl]-5-oxo-, (2R)-;KMN80,KMN 80;7-((R)-2-((3S,4S,E)-3-hydroxy-4-methylnon-1-en-6-yn-1-yl)-5-oxopyrrolidin-1-yl)heptanoicacid;7-[(2R)-2-[(E,3S,4S)-3-Hydroxy-4-methylnon-1-en-6-ynyl]-5-oxopyrrolidin-1-yl]heptanoic acid | | CAS: | 1628759-75-0 | | MF: | C21H33NO4 | | MW: | 363.49 | | EINECS: | | | Product Categories: | | | Mol File: | 1628759-75-0.mol |  |
| | KMN-80 Chemical Properties |
| Boiling point | 572.1±50.0 °C(Predicted) | | density | 1.121±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 20 mg/ml; DMSO: 15 mg/ml; Ethanol: 25 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml | | form | A crystalline solid | | pka | 4.77±0.10(Predicted) |
| | KMN-80 Usage And Synthesis |
| Description | The prostaglandin E receptor 4 (EP4) is one of four G protein-coupled receptors that mediate the actions of prostaglandin E2 (PGE2; ). Binding of PGE2 to the EP4 receptor causes an increase in intracellular cyclic AMP, which plays important roles in bone formation and resorption, cancer, and atherosclerosis.1,2,3,4 KMN-80 is a substituted γ-lactam (pyrrolidinone) derivative of PGE1 that acts as a selective and potent agonist of EP4 with an IC50 value of 3 nM (IC50 = 1.4 μM for EP3 and > 10 μM for all other prostanoid receptors).5 In functional assays it has been shown to stimulate secreted alkaline phosphatase gene reporter activity in EP4-transfected HEK293 cells with an EC50 value of 0.19 nM, demonstrating >5,000 and 50,000-fold selectivity against EP2 and TP, respectively.5 KMN-80 can induce the differentiation of bone marrow stem cells from both young and aged rats into osteoblasts in vitro (EC50s = 20 and 153 nM, respectively) and exhibits favorable tolerability up to at least 10 μM, whereas the EP4 agonist L-902,688 is highly cytotoxic at similar concentrations in these cells.6 KMN-80 has been used to repair calvarial defects in an in vivo rat craniomaxillofacial reconstruction model (rate of reduction in defect size equivalent to BMP-2 treated rats) and to promote bone formation in a rat incisor tooth socket model.6 | | References | 1. Li, M., Thompson, D.D., and Paralkar, V.M. Prostaglandin E2 receptors in bone formation Int. Orthop. 31(6),767-772(2007).
2. Hawcroft, G., Ko, C.W.S., and Hull, M.A. Prostaglandin E2-EP4 receptor signalling promotes tumorigenic behaviour of HT-29 human colorectal cancer cells Oncogene 26(21),3006-3019(2007).
3. Babaev, V.R., Chew, J.D., Ding, L., et al. Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosis Cell Metab. 8(6),492-501(2008).
4. Konya, V., Marsche, G., Schuligoi, R., et al. E-type prostanoid receptor 4 (EP4) in disease and therapy Pharmacol. Ther. 138(3),485-502(2013).
5. Barrett, S.D., Ciske, F.L., Endres, G.W., et al. Novel Potent Lactam Acetylene EP4 Agonists Stimulate Alkaline Phosphatase Production and Differentiation in Bone Marrow Cells ,(2014).
6. O'Malley, J., Uzieblo, A., Germain, B.D., et al. Development of a novel prostaglandin EP4 agonist which stimulates local bone formation in vivo ,(2014). |
| | KMN-80 Preparation Products And Raw materials |
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