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2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid

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2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid manufacturers

  • Evatanepag
  • Evatanepag pictures
  • $64.00
  • 2026-08-04
  • CAS:223488-57-1
  • Purity: 99.68%
  • Supply Ability: 10g
2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid Basic information
Product Name:2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid
Synonyms:EVATANEPAG;CP-533536;CP 533536;CP-533536;CP 533536;CP533536;(3-(((4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino)-methyl)-phenoxy)-acetic acid;Evatanepag (CP-533536);CS-2325;2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid;CP-533536 free acid;Acetic acid, 2-[3-[[[[4-(1,1-dimethylethyl)phenyl]methyl](3-pyridinylsulfonyl)amino]methyl]phenoxy]-
CAS:223488-57-1
MF:C25H28N2O5S
MW:468.57
EINECS:
Product Categories:
Mol File:223488-57-1.mol
2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid Structure
2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid Chemical Properties
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMSO:32.0(Max Conc. mg/mL);68.29(Max Conc. mM)
form Solid
color White to off-white
Safety Information
MSDS Information
2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid Usage And Synthesis
UsesEvatanepag is an EP2 receptor selective prostaglandin E2 agonist that helps induce bone growth.
DefinitionChEBI: Evatanepag is a monocarboxylic acid.
in vivo

Evatanepag (0.3-3.0 mg/kg, directly injected into the marrow cavity of the tibia) promotes bone formation in rats[1].
Evatanepag (0.3, 3.0 mg/kg, intranasal administration, from day1 to day4) reduces HDM aeroallergen-induced increased RL response to methacholine in mice[2].
Evatanepag (1 mg/kg, intravenous injection) demonstrates high i.v. clearance (Cl: 56 mL/min/kg) and a short half-life (t1/2: 0.33 h)[1].

Animal Model:Rats[1]
Dosage:0.3, 1.0, 3.0 mg/kg
Administration:Directly injected into the marrow cavity of the tibia
Result:Dose-dependently increased in bone area, bone mineral content, bone mineral density.
Animal Model:HDM (house dust mite)-sensitized BALB/c mice[2]
Dosage:0.3 mg/kg, 3 mg/kg
Administration:Intranasal administration, from day1 to day4
Result:Prevented aeroallergen-driven increased RL (lung resistance) at 0.3 mg/kg.
Prevented the enhanced MC activity by approximately 48% at 3 mg/kg.
IC 50EP2
2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid Preparation Products And Raw materials
Tag:2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid(223488-57-1) Related Product Information
N-Methylformamide sodium salt of (3-(((4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino)-methyl)-phenoxy)-acetic acid 2-[3-[N-(4-tert-Butylbenzyl)-N-(pyridin-3-ylsulfonyl)aminomethyl]phenoxy]acetic acid CP 544326 BAVACHIN KMN-80