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| | UR-144 Degradant Basic information |
| Product Name: | UR-144 Degradant | | Synonyms: | UR-144 Degradant;NBJHWTCAQOYUND-UHFFFAOYSA-N;3,?3,?4-?Trimethyl-?1-?(1-?pentyl-?1H-?indol-?3-?yl)?-4-?penten-?1-?one;4-Penten-1-one, 3,3,4-trimethyl-1-(1-pentyl-1H-indol-3-yl)- | | CAS: | 1609273-88-2 | | MF: | C21H29NO | | MW: | 311.46 | | EINECS: | | | Product Categories: | | | Mol File: | 1609273-88-2.mol |  |
| | UR-144 Degradant Chemical Properties |
| Boiling point | 447.3±28.0 °C(Predicted) | | density | 0.96±0.1 g/cm3(Predicted) | | solubility | DMF: 5 mg/ml; DMSO: 5 mg/ml; Ethanol: 12.5 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml |
| | UR-144 Degradant Usage And Synthesis |
| Description | UR-144 is a synthetic cannabinoid (CB) analog of JWH 018 in which the naphthalene ring is substituted with a tetramethylcyclopropyl group. This substitution results in a compound which is a potent agonist for the peripheral CB2 receptor. UR-144 Degradant is a common impurity observed during GC-MS analysis of samples containing UR-144. The opened ring of the degradant is presumed to be produced during heating of UR-144. This structure gives rise to a prominent fragment ion that is 15 amu greater than the base peak of UR-144. This pattern is consistent with McLafferty rearrangement of the degradant which does not occur with the parent compound. | | Uses | 3,3,4-Trimethyl-1-(1-pentyl-1H-indol-3-yl)-4-penten-1-one is a potent agonist for the peripheral CB2 receptor and a synthetic cannabinoid. It can be used to develop analytical assays that detects UR-144 and its metabolites. | | References | [1] MCLAFFERTY F W. Mass Spectrometric Analysis. Molecular Rearrangements[J]. Analytical Chemistry, 1959, 31 1: 82-87. DOI: 10.1021/ac60145a015
[2] THOMAS B, LEFEVER T, CORTES R A, et al. Thermolytic Degradation of Synthetic Cannabinoids: Chemical Exposures and Pharmacological Consequences[J]. The Journal of Pharmacology and Experimental Therapeutics, 2017, 9 1: 0. DOI: 10.1124/jpet.116.238717 |
| | UR-144 Degradant Preparation Products And Raw materials |
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