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| | Carboxy-PEG4-sulfonic acid Basic information |
| | Carboxy-PEG4-sulfonic acid Chemical Properties |
| density | 1.328±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | solubility | Soluble in Water | | pka | 1.34±0.50(Predicted) | | form | Viscous Liquid | | color | Colorless to light yellow |
| | Carboxy-PEG4-sulfonic acid Usage And Synthesis |
| Description | Carboxy-PEG4-sulfonic acid is a PEG linker containing carboxylic acid and sulfonic acid. The terminal carboxylic acid can participate in reactions with primary amines in the presence of activators such as EDC and HATU. The sulfonic acid group can undergo esterification, halogenation and replacement reactions. The hydrophilic PEG linker increases solubility of a compound in aqueous media. | | Uses | Carboxy-PEG4-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Carboxy-PEG4-sulfonic acid Preparation Products And Raw materials |
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