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| | Carboxy-PEG2-sulfonic acid Basic information |
| | Carboxy-PEG2-sulfonic acid Chemical Properties |
| density | 1.425±0.06 g/cm3(Predicted) | | solubility | Soluble in Water | | pka | 1.34±0.50(Predicted) |
| | Carboxy-PEG2-sulfonic acid Usage And Synthesis |
| Description | Carboxy-PEG2-sulfonic acid is a PEG linker containing a carboxylic acid and sulfonic acid end group. The terminal carboxylic acid can participate in reactions with primary amines in the presence of activators such as EDC and HATU. Sulfonic acid can undergo esterification, halogenation and replacement reactions. The hydrophilic PEG linker increases the compound's water solubility in aqueous media. | | Uses | Carboxy-PEG2-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Carboxy-PEG2-sulfonic acid Preparation Products And Raw materials |
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