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Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2

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Company Name: Bide Pharmatech Ltd.  
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Company Name: Guangzhou Zhiya Chemdrugs Co.,Ltd  
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Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Tel: 15026964105
Email: 2881489226@qq.com

Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2 manufacturers

  • LY2510924
  • LY2510924 pictures
  • $1940.00
  • 2026-08-04
  • CAS:1088715-84-7
  • Purity:
  • Supply Ability: 10g
Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2 Basic information
Product Name:Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2
Synonyms:Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2;LY2510924; LY-2510924; LY 2510924;CS-2675;Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2A;L-Lysinamide, L-phenylalanyl-L-tyrosyl-N6-(1-methylethyl)-L-lysyl-D-arginyl-3-(2-naphthalenyl)-L-alanylglycyl-D-α-glutamyl-N6-(1-methylethyl)-, (7→1)-lactam;(2S,5S,8S,11R,14S,20R)-N-((S)-1-Amino-6-(isopropylamino)-1-oxohexan-2-yl)-2-benzyl-11-(3-guanidinopropyl)-5-(4-hydroxybenzyl)-8-(4-(isopropylamino)butyl)-14-(naphthalen-2-ylmethyl)-3,6,9,12,15,18,23-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosane-20-carboxamide;LY2510924 TFA salt;LY-2510924 (LY2510924)
CAS:1088715-84-7
MF:C62H88N14O10
MW:1189.45
EINECS:
Product Categories:
Mol File:1088715-84-7.mol
Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2 Structure
Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2 Chemical Properties
density 1.33±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : ≥ 125 mg/mL (105.09 mM)
form Solid
pka9.89±0.15(Predicted)
color White to off-white
InChIKeyIJHWVENTEFSNBC-QBSDWBABNA-N
Safety Information
MSDS Information
Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2 Usage And Synthesis
UsesLY2510924 is a CXC chemokine receptor 4 inhibitor and a potential antineoplastic agent.
in vivo

LY2510924 specifically blocks SDF-1 binding to CXCR4 with IC50 value of 0.079 nM, and inhibits SDF-1–induced GTP binding with Kb value of 0.38 nM. In human lymphoma U937 cells expressing endogenous CXCR4, LY2510924 inhibits SDF-1–induced cell migration with IC50 value of 0.26 nM and inhibits SDF-1/CXCR4-mediated intracellular signaling. LY2510924 exhibits a concentration-dependent inhibition of SDF-1–stimulated phospho-ERK and phospho-Akt in tumor cells. Biochemical and cellular analyses reveals that LY2510924 has no apparent agonist activity[1]. LY2510924 chiefly inhibits the proliferation of AML cells with little induction of cell death and reduces protection against chemotherapy by stromal cells[2].

IC 50125I-SDF-1α-CXCR4: 79.7 pM (IC50); 125I-SDF-1α-CXCR4: 49.5 pM (Ki)
Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2 Preparation Products And Raw materials
Raw materialsMethanol-->Acetic acid
Tag:Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2(1088715-84-7) Related Product Information
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