NucPE1 manufacturers
- NucPE1
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2026-07-15
- CAS:1404091-23-1
- Purity:
- Supply Ability: 10g
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| Product Name: | NucPE1 | | Synonyms: | NucPE1;Nuclear Peroxy Emerald 1, >98%;NUCPE1?, >98%;Nuclear Peroxy Emerald 1;3'-(ethylamino)-2'-methyl-6'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[2-benzofuran-3,9'-xanthene]-1-one;Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3'-(ethylamino)-2'-methyl-6'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- | | CAS: | 1404091-23-1 | | MF: | C29H30BNO5 | | MW: | 483.36 | | EINECS: | | | Product Categories: | | | Mol File: | 1404091-23-1.mol |  |
| | NucPE1 Chemical Properties |
| Boiling point | 643.5±55.0 °C(Predicted) | | density | 1.26±0.1 g/cm3(Predicted) | | pka | 3.40±0.20(Predicted) | | form | Solid | | color | White to off-white |
| | NucPE1 Usage And Synthesis |
| Uses | NucPE1 (Nuclear Peroxy Emerald 1) is a nuclear-localized fluorescent hydrogen peroxide that is specifically localized to cellular nuclei without appended targeting moieties. | | in vivo | NucPE1 maintains the ability to selectively target nuclei in vivo. NucPE1 imaging reveals a reduction in nuclear H2O2 levels in worms overexpressing sir-2.1 compared to wildtype congeners, supporting a link between this longevity-promoting sirtuin protein and enhanced regulation of nuclear ROS pools[1]. | | References | [1] Stanicka J, et al. NADPH oxidase-generated hydrogen peroxide induces DNA damage in mutant FLT3-expressing leukemia cells. J Biol Chem. 2015 Apr 10;290(15):9348-61. DOI:10.1074/jbc.M113.510495
[2] Dickinson BC, et al. A nuclear-localized fluorescent hydrogen peroxide probe for monitoring sirtuin-mediated oxidative stress responses in vivo. Chem Biol. 2011 Aug 26;18(8):943-8. DOI:10.1016/j.chembiol.2011.07.005 |
| | NucPE1 Preparation Products And Raw materials |
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