SC57666

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SC57666 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:SC57666
CAS:158959-32-1
Purity:98.00% Package:1 mg；1 mL * 10mM (in DMSO)；10 mg；100 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: MedChemexpress LLC  
Tel: 021-58955995
Email: sales@medchemexpress.cn
Products Intro: Product Name:SC57666
CAS:158959-32-1
Purity:320RMB/1mg Package:>98%
Company Name: BOC Sciences  
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Email: info@bocsci.com
Products Intro: Product Name:SC57666
CAS:158959-32-1
Remarks:A selective COX2 inhibitor (IC50= 26 nM)
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Email: sales@chemegen.com
Products Intro: Product Name:SC57666
CAS:158959-32-1
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
Company Name: Shanghai hongqu biomedical technology co. LTD  
Tel: 88888888888
Email: hongquchem@qq.com
Products Intro: Product Name:SC57666
CAS:158959-32-1
Purity:98% Package:100mg;1g;10g;100g;1kg
SC57666 Basic information
Product Name:SC57666
Synonyms:SC57666;Benzene, 1-fluoro-4-[2-[4-(methylsulfonyl)phenyl]-1-cyclopenten-1-yl]-;SC57666,SC-57666;SC57666, 10 mM in DMSO
CAS:158959-32-1
MF:C18H17FO2S
MW:316.39
EINECS:
Product Categories:
Mol File:158959-32-1.mol
SC57666 Structure
SC57666 Chemical Properties
Melting point 146-147 °C
Boiling point 472.1±45.0 °C(Predicted)
density 1.253±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: ≥ 100 mg/mL (316.07 mM)
form Solid
color White to off-white
Safety Information
MSDS Information
SC57666 Usage And Synthesis
UsesSC57666 is a selective COX2 inhibitor with an IC50 of 26 nM.
DefinitionChEBI: SC-57666 is a stilbenoid.
in vivo

SC57666 has been shown to be orally active (ED50=1.7 mpk) in the adjuvant-induced arthritis model. No gastric lesions are observed in mice after 5 h when SC57666 is administered intragastrically at 600 mpk. No intestinal damage is observed in rats after 72 h when SC57666 is administered intragastrically at 200 mpk[1].

IC 50COX-2: 26 nM (IC50)
References[1] Reitz DB, et al. Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally activeCOX2 inhibitors. J Med Chem. 1994 Nov 11;37(23):3878-81. DOI:10.1021/jm00049a005
[2] Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. DOI:10.1038/sj.bjp.0701076
SC57666 Preparation Products And Raw materials
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