4-Pyridinecarboxamide, N-[4-(2,4-dimethylphenyl)-2-thiazolyl]-

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4-Pyridinecarboxamide, N-[4-(2,4-dimethylphenyl)-2-thiazolyl]- Basic information
Product Name:4-Pyridinecarboxamide, N-[4-(2,4-dimethylphenyl)-2-thiazolyl]-
Synonyms:4-Pyridinecarboxamide, N-[4-(2,4-dimethylphenyl)-2-thiazolyl]-;N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]-4-pyridinecarboxamide;N-[4-(2,4-Dimethylphenyl)thiazol-2-yl]isonicotinamide;Nek2/Hec1-IN-1
CAS:560103-80-2
MF:C17H15N3OS
MW:309.39
EINECS:
Product Categories:
Mol File:560103-80-2.mol
4-Pyridinecarboxamide, N-[4-(2,4-dimethylphenyl)-2-thiazolyl]- Structure
4-Pyridinecarboxamide, N-[4-(2,4-dimethylphenyl)-2-thiazolyl]- Chemical Properties
Melting point 150 °C
density 1.278±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: soluble
form powder to crystal
pka5.40±0.70(Predicted)
color White to Light yellow to Light orange
Safety Information
HS Code 2934.10.9000
MSDS Information
4-Pyridinecarboxamide, N-[4-(2,4-dimethylphenyl)-2-thiazolyl]- Usage And Synthesis
UsesN-[4-(2,4-Dimethylphenyl)-2-thiazolyl]-4-pyridinecarboxamide is a derivative of INH1 with anticancer activity. It is cytotoxic to MDA-MB-231, MDA-MB-488, HeLa, and K562 cells (IC50s=1.1, 3.4, 1.6, and 1.2 μM, respectively).
References[1] Qiu, et al. Synthesis and biological evaluation of a series of novel inhibitor of Nek2/Hec1 analogues. J. Med. Chem. 52(6), 1757-1767 (2009).
4-Pyridinecarboxamide, N-[4-(2,4-dimethylphenyl)-2-thiazolyl]- Preparation Products And Raw materials
Raw materials4-(2,4-Dimethyl-phenyl)-thiazol-2-ylamine-->Isonicotinoyl chloride hydrochloride
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