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| | YMYFRDZTZVZUPF-MNJXXUMNSA-N Basic information |
| Product Name: | YMYFRDZTZVZUPF-MNJXXUMNSA-N | | Synonyms: | YMYFRDZTZVZUPF-MNJXXUMNSA-N;AS2521780
(AS 2521780;5-Pyrimidinecarbonitrile, 4-[[[(3R,5S)-4-[[(trans-4-hydroxycyclohexyl)methyl]amino]tricyclo[3.3.1.13,7]dec-1-yl]methyl]amino]-2-[[[2-(methylthio)-3-pyridinyl]methyl]amino]-, rel-;4-[[(4-(methylthio)pyridin-2-yl)methyl]amino]-6-((((3R,5S)-3-((trans-4-hydroxycyclohexyl)methylamino)adamantan-1-yl)methyl)amino)pyrimidine-5-carbonitrile | | CAS: | 1214726-89-2 | | MF: | C30H41N7OS | | MW: | 547.77 | | EINECS: | | | Product Categories: | | | Mol File: | 1214726-89-2.mol |  |
| | YMYFRDZTZVZUPF-MNJXXUMNSA-N Chemical Properties |
| Boiling point | 791.5±70.0 °C(Predicted) | | density | 1.29±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 15.24±0.40(Predicted) |
| | YMYFRDZTZVZUPF-MNJXXUMNSA-N Usage And Synthesis |
| Description | AS2521780 is a potent and selective PKCθ inhibitor. | | Uses | AS2521780 is a novel PKCθ selective inhibitor with an IC50 of 0.48 nM. | | in vivo | AS2521780 significantly reduces paw swelling in a dose-dependent manner in a rat model of adjuvant-induced arthritis[1]. | | IC 50 | PKCθ: 0.48 nM (IC50); PKCε: 18 nM (IC50); PKCα: 160 nM (IC50); PKCδ: 160 nM (IC50) | | References | [1] Fukahori H, et al. Effect of AS2521780, a novel PKCθ selective inhibitor, on T cell-mediated immunity. Eur J Pharmacol. 2014 Dec 15;745:217-22. DOI:10.1016/j.ejphar.2014.10.045 |
| | YMYFRDZTZVZUPF-MNJXXUMNSA-N Preparation Products And Raw materials |
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