| Company Name: |
T&W GROUP |
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021-61551611 13296011611 |
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contact@trustwe.com |
- Prostratin
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- $211.00
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2026-07-27
- CAS:60857-08-1
- Purity:
- Supply Ability: 10g
- Prostratin
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- $10.00
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2023-08-04
- CAS:60857-08-1
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 500t/month
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| | Prostratin, PKC activator Basic information |
| Product Name: | Prostratin, PKC activator | | Synonyms: | SA 101A;Prostatin >99%;12-Deoxyphorbol 13-Acetate, dPAc;(1aR,1bS,4aR,7aS,7bR,8R,9aS)-9a-(Acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a
-decahydro-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl-;13-O-Acetyl-12-deoxyphorbol;(1aR,1bS,4aR,7aS,7bR,8R,9aS)-9a-(Acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a -decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl- 5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one;13-O-Acetylphorbol;NSC 623310 | | CAS: | 60857-08-1 | | MF: | C22H30O6 | | MW: | 390.47 | | EINECS: | | | Product Categories: | Activator;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Protein Kinase Inhibitors and Activators | | Mol File: | 60857-08-1.mol |  |
| | Prostratin, PKC activator Chemical Properties |
| Melting point | 216-219℃ | | Boiling point | 550.5±50.0 °C(Predicted) | | density | 1.31 | | storage temp. | -20°C | | solubility | Soluble in DMSO at 30mg/ml | | form | white powder | | pka | 11.40±0.70(Predicted) | | color | Off-white | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. | | InChIKey | BOJKFRKNLSCGHY-HXGSDTCMSA-N | | SMILES | C[C@@H]1C[C@]2(OC(C)=O)[C@H]([C@@H]3C=C(CO)C[C@@]4(O)[C@@H](C=C(C)C4=O)[C@@]13O)C2(C)C |
| WGK Germany | 3 | | HS Code | 2916200090 | | Storage Class | 11 - Combustible Solids |
| | Prostratin, PKC activator Usage And Synthesis |
| Description | Activation of latent reservoirs of HIV-infected cells is a treatment strategy designed to reduce viral load and eliminate the perpetuation of retroviral infection. Prostratin is a non-tumor promoting phorbol ester that potently induces HIV-1 reactivation in latent reservoirs of infected Jurkat-LAT-GFP cells with an IC50 value of ~0.5 μM. Originally, prostratin was isolated from plant sources including P. prostrata, E. cornigera, and H. nutans. The effects of prostratin are mediated through activation of NF-κB via protein kinase C and by downregulation of HIV-1 receptor CD4 expression and its co-receptors CXCR4 and CCR5. | | Uses | Activation of latent reservoirs of HIV-infected cells is a treatment strategy designed to reduce viral load and eliminate the perpetuation of retroviral infection. Prostratin is a non-tumor promoting phorbol ester that potently induces HIV-1 reactivation in latent reservoirs of infected Jurkat-LAT-GFP cells . [Cayman Chemical] | | Definition | ChEBI: A natural product found in Euphorbia fischeriana. | | Biochem/physiol Actions | Prostratin, an unusual non-tumorigenic phorbol ester, is an activator of protein kinase C (PKC) and also an activator of nuclear factor KB (NF-KB) mediated through activation of the IKKs (IKB kinases). Prostratin exhibits potent in vitro activity by inducing HIV expression in latently infected cell lines and primary cells, thus antagonizing HIV latency. Activation of PKC and NF-kB has been proposed as the mechanism of action. Prostratin also inhibits HIV entry into target cells by down-regulating CD4 and CXCR4 receptors. | | IC 50 | PKC: 12.5 nM (Ki); HIV-1 | | References | [1] A.R. CASHMORE ∗ . The structure of prostratin : a toxic tetracyclic diterpene ester from Pimelea Prostrata[J]. Tetrahedron Letters, 1976, 17 20: Pages 1737-1738. DOI:10.1016/s0040-4039(00)92940-x
[2] GHULAM ABBAS MIANA. Prostratin: An Overview.[J]. Mini reviews in medicinal chemistry, 2015, 15 13: 1122-1130. DOI:10.2174/1389557515666150511154108
[3] XING SHEN . The protein kinase C agonist prostratin induces differentiation of human myeloid leukemia cells and enhances cellular differentiation by chemotherapeutic agents[J]. Cancer letters, 2015, 356 2: Pages 686-696. DOI:10.1016/j.canlet.2014.10.018
[4] ANGÉLIQUE BIANCOTTO. Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissue.[J]. Journal of Virology, 2004, 78 19: 10507-10515. DOI:10.1128/jvi.78.19.10507-10515.2004
[5] NOELIA GERIBALDI-DOLDÁN. 12-Deoxyphorbols Promote Adult Neurogenesis by Inducing Neural Progenitor Cell Proliferation via PKC Activation.[J]. International Journal of Neuropsychopharmacology, 2015, 19 1. DOI:10.1093/ijnp/pyv085 |
| | Prostratin, PKC activator Preparation Products And Raw materials |
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