| Company Name: |
MQ (shanghai) Pharmaceuticals Co., Ltd.
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| Tel: |
13761635123 |
| Email: |
sales@linyuepharm.com |
| Products Intro: |
Product Name:CPTH2 hydrochloride , CPTH2 HCl
CAS:2108899-91-6
Purity:＞95% Package:1G，5G
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| Company Name: |
Angel Pharmatech, Ltd.
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| Tel: |
17317130613 |
| Email: |
3358272972@qq.com |
| Products Intro: |
Product Name:CPTH2 (hydrochloride)
CAS:2108899-91-6
Package:1g/
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:CPTH2 hydrochloride
CAS:2108899-91-6
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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ODVWZAKKCNHATB-UHFFFAOYSA-N manufacturers
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| | ODVWZAKKCNHATB-UHFFFAOYSA-N Basic information |
| Product Name: | ODVWZAKKCNHATB-UHFFFAOYSA-N | | Synonyms: | ODVWZAKKCNHATB-UHFFFAOYSA-N;2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone-cyclopentanone,monohydrochloride;CPTH2 hydrochloride , CPTH2 HCl | | CAS: | 2108899-91-6 | | MF: | C14H15Cl2N3S | | MW: | 328.26 | | EINECS: | | | Product Categories: | | | Mol File: | 2108899-91-6.mol |  |
| | ODVWZAKKCNHATB-UHFFFAOYSA-N Chemical Properties |
| solubility | DMF: 5 mg/ml; DMSO: 16 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.30 mg/ml; Ethanol: 5 mg/ml | | form | A crystalline solid |
| | ODVWZAKKCNHATB-UHFFFAOYSA-N Usage And Synthesis |
| Description | Gcn5 is a chromatin modifying factor whose HAT activity is required to acetylate histone H3 lysine 9 (K9) and K14, which facilitates transcription elongation by relaxing nucleosomes. CPTH2 inhibits the HAT activity of Gcn5 both in vitro and in vivo, reducing histone H3K14 acetylation at a concentration of 0.8 mM. It is a useful tool to study the impact of Gcn5-dependent acetylation in various biological systems and recently has been used to control the replication of human adenovirus. | | Uses | CPTH2 hydrochloride is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 hydrochloride selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 hydrochloride induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B)[1][2]. | | IC 50 | GCN5 | | References | [1] Cocco E, et al. KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumoraggressiveness and target of KAT inhibitor CPTH2. Clin Epigenetics. 2018 Apr 4;10:44. DOI:10.1186/s13148-018-0473-4
[2] Chimenti F, et al. A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. J Med Chem. 2009 Jan 22;52(2):530-6. DOI:10.1021/jm800885d |
| | ODVWZAKKCNHATB-UHFFFAOYSA-N Preparation Products And Raw materials |
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