|
|
| | 2-Chloro-N,N-dimethylacetamide Basic information |
| Product Name: | 2-Chloro-N,N-dimethylacetamide | | Synonyms: | N,N-DIMETHYL-2-CHLOROACETAMIDE;N,N-DIMETHYLCHLOROACETAMIDE;N,N-DIMETHYLCHOROACETAMIDE;CHLOROACETYLDIMETHYLAMINE;AKOS BBS-00000943;2-CHLORO-N,N-DIMETHYLACETAMIDE;2-chloro-N,N-dimethyl-ethanamide;2-Chloro-N,N-dimethylacetacetamide | | CAS: | 2675-89-0 | | MF: | C4H8ClNO | | MW: | 121.57 | | EINECS: | 220-224-4 | | Product Categories: | 2675-89-0 | | Mol File: | 2675-89-0.mol |  |
| | 2-Chloro-N,N-dimethylacetamide Chemical Properties |
| Melting point | 15-16 °C | | Boiling point | 98-100°C/11mm | | density | 1.182 g/mL at 20 °C (lit.) | | refractive index | n20/D 1.479 | | Fp | 98-100°C/11mm | | storage temp. | Store below +30°C. | | solubility | Chloroform (Slightly), Hexane (Slightly), Methanol (Slightly) | | pka | -0.95±0.70(Predicted) | | form | Liquid | | color | Clear colorless to pale yellow | | BRN | 969568 | | InChI | 1S/C4H8ClNO/c1-6(2)4(7)3-5/h3H2,1-2H3 | | InChIKey | XBPPLECAZBTMMK-UHFFFAOYSA-N | | SMILES | CN(C)C(=O)CCl | | CAS DataBase Reference | 2675-89-0(CAS DataBase Reference) |
| Hazard Codes | C | | Risk Statements | 22-34 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 3265 8/PG 3 | | WGK Germany | 3 | | HazardClass | 8 | | HS Code | 29241990 | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Acute Tox. 4 Oral
Skin Corr. 1B |
| | 2-Chloro-N,N-dimethylacetamide Usage And Synthesis |
| Uses | 2-Chloro-N,N-dimethylacetamide is N,M-dialkyl amide used as an organic catalyst in the preparation of phosphorylated thiosemicarbazide. | | Uses | 2-Chloro-N,N-dimethylacetamide (N,N-dimethylchloroacetamide) was used in the synthesis of (S)-carbinoxamine. | | Synthesis | In a 500 mL four-necked flask, sodium hydrogen carbonate 126.0 g (1.50 mol) and 146.8 g of toluene were added, and the mixture was stirred while cooling. The internal temperature was maintained below 5 ° C, 112.9 g (1.00 mol) of chloroacetyl chloride was added dropwise over 4 hours, and 49.6 g (1.10 mol) of dimethylamine gas was blown over 4 hours. After stirring at -2 to 1 ° C. for 1 hour, the reaction solution was filtrated under reduced pressure to remove inorganic salt crystals by filtration. The crystals were washed with 100 g of toluene, and the filtrate and washings were combined. After separating and removing the aqueous layer in the filtrate washings, the toluene layer was concentrated under reduced pressure to obtain 113.2 g (0.93 mol) of oily 2-chloro-N, N-dimethylacetamide. The yield was 93.1%.
 |
| | 2-Chloro-N,N-dimethylacetamide Preparation Products And Raw materials |
|