呋喃茶碱
| 中文名称 | 呋喃茶碱 |
|---|---|
| 中文同义词 | 呋喃茶碱;呋喃菲林;呋拉茶碱;3-(呋喃-2-基甲基)-1,8-二甲基-1H-嘌呤-2,6(3H,7H)-二酮;呋喃茶碱标准品;FURAFYLLINE,PDE抑制剂;呋拉茶碱,10 MM DMSO 溶液 |
| 英文名称 | 3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE |
| 英文同义词 | 3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE;Furafylline,3-(2-Furanylmethyl)-3,7-dihydro-1,8-dimethyl-1H-purine-2,6-dione;FURAFYLLINE INHIBITOR OF CYTOCHRO;1H-Purine-2,6-dione, 3-(2-furanylmethyl)-3,9-dihydro-1,8-dimethyl-;3-(Furan-2-ylmethyl)-1,8-dimethyl-1H-purine-2,6(3H,7H)-dione;Cytochrome P450,inhibit,Inhibitor,CYPs,Furafylline;Furatheophylline;Furafilina |
| CAS号 | 80288-49-9 |
| 分子式 | C12H12N4O3 |
| 分子量 | 260.25 |
| EINECS号 | 200-158-5 |
| 相关类别 | 试剂 |
| Mol文件 | 80288-49-9.mol |
| 结构式 |  |
呋喃茶碱 性质
| 熔点 | >162°C (dec.) |
|---|---|
| 沸点 | 543.6±60.0 °C(Predicted) |
| 密度 | 1.443±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C(protect from light) |
| 溶解度 | 乙醇：0.33 mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 8.62±0.70(Predicted) |
| 颜色 | 白色 |
| InChI | InChI=1S/C12H12N4O3/c1-7-13-9-10(14-7)16(6-8-4-3-5-19-8)12(18)15(2)11(9)17/h3-5H,6H2,1-2H3,(H,13,14) |
| InChIKey | KGQZGCIVHYLPBH-UHFFFAOYSA-N |
| SMILES | N1C2=C(N(CC3=CC=CO3)C(=O)N(C)C2=O)NC=1C |
Furafylline 是一种有效且有选择性的人细胞色素 P450IA2 抑制剂，其 IC50 值为 0.07 μM。
IC50: 0.07 μM (human cytochrome P450IA2)
Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC 50 of 0.07 μM in kinase experiment. Furafylline is a methylxanthine derivative that is introduced as a long-acting replacement for theophylline in the treatment of asthma. Administration of Furafylline is associated with an elevation in plasma levels of caffeine, due to inhibition of caffeine oxidation, a reaction catalysed by one or more hydrocarbon-inducible isoenzymes of P450. Furafylline has either very little or no effect on human monooxygenase activities catalysed by other isoenzymes of P450, including P4501ID1, P4501IC, P450IIIA.
安全信息
| WGK Germany | 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 提供商 | 语言 |
|---|---|
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-107204R | 呋喃茶碱 Furafylline (Standard) | 80288-49-9 | 1 mg | 2100元 |
| 2026/06/05 | HY-107204R | 呋喃茶碱 Furafylline (Standard) | 80288-49-9 | 5 mg | 5250元 |