| Company Name: |
TCI Europe |
| Tel: |
320-37350700 |
| Email: |
sales@tcieurope.eu |
- Roquinimex
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- $30.00
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2026-07-27
- CAS:84088-42-6
- Purity: 99.65%
- Supply Ability: 10g
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| | Roquinimex Basic information |
| Product Name: | Roquinimex | | Synonyms: | N-PHENYLMETHYL-1,2-DIHYDRO-4-HYDROXYL-N,1-DIMETHYL-2-OXO-QUINOLINE-3-CARBOXAMIDE;ROQUINIMEX;LINOMIDE;LS-2616;1,2-DIHYDRO-4-HYDROXY-N,1-DIMETHYL-2-OXO-N-PHENYL-3-QUINOLINECARBOXAMIDE;1,2-DIHYDRO-4-HYDROXY-N,N-DIMETHYL-2-OXO-N-PHENYL-3-QUINOLINECARBOXAMIDE;CS-1231;Roquinimex(Linomide) | | CAS: | 84088-42-6 | | MF: | C18H16N2O3 | | MW: | 308.33 | | EINECS: | | | Product Categories: | Antitumour | | Mol File: | 84088-42-6.mol |  |
| | Roquinimex Chemical Properties |
| Melting point | 200-204° | | Boiling point | 436.2±45.0 °C(Predicted) | | density | 1.357±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | solubility | DMSO: 11 mg/mL | | form | solid | | pka | 4.50±1.00(Predicted) | | color | White to off-white | | Merck | 14,8259 |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 36/37 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | HS Code | 2933.49.2600 |
| | Roquinimex Usage And Synthesis |
| Description | Roquinimex is an immunomodulator with diverse biological activities. In vivo, roquinimex (80 mg/kg) increases the number of myocardial MHC class II-expressing cells, the ratio of cytotoxic to helper T cells, and survival and decreases necrotic lesion area in a mouse model of murine coxsackievirus B3-induced myocarditis. It induces IFN-γ production, reduces TNF-α and IL-1β production, prevents the development of proteinuria, and ameliorates nephritis in a mouse model of chronic graft versus host disease (GVHD). Roquinimex (300 mg/kg) decreases colonic myeloperoxidase (MPO) activity and mucosal damage in a mouse model of colitis induced by dextran sulfate (DSS; ). It also decreases tumor weight and tumor blood flow in a von Hippel-Lindau (VHL) type 2a paraganglioma mouse xenograft model. | | Uses | Biological response modifier; immunomodulator. | | Uses | An immunomodulator with antitumour properties. Inhibits T-cell apoptosis in vivo; also inhibits angiogenesis in rats | | Definition | ChEBI: 4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide is an aromatic amide. | | Biological Activity | Immunomodulator with stimulatory and antitumor properties. Inhibits in vivo apoptosis of T-cells and inhibits angiogenesis in rats in vivo . | | References | [1] N. ILBCK. Effects of the immunomodulator LS 2616 on lymphocyte subpopulations in murine Coxsackievirus B3 myocarditis.[J]. Journal of immunology, 1989, 142 9 1: 3225-3228. DOI: 10.4049/jimmunol.142.9.3225
[2] ZHI-YONG XIAO. Roquinimex-mediated protection effect on the development of chronic graft-versus-host disease in mice is associated with induction of Th1 cytokine production and inhibition of proinflammatory cytokine production[J]. Life sciences, 2007, 81 19: Pages 1403-1410. DOI: 10.1016/j.lfs.2007.08.044
[3] Q LIU. Roquinimex inhibits dextran sodium sulfate-induced murine colitis.[J]. Inflammation Research, 2003, 52 2: 64-68. DOI: 10.1007/s000110300002
[4] D J GROSS. The antiangiogenic agent linomide inhibits the growth rate of von Hippel-Lindau paraganglioma xenografts to mice.[J]. Clinical Cancer Research, 1999, 5 11: 3669-3675.
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| | Roquinimex Preparation Products And Raw materials |
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