6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one

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6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one manufacturers

  • Bragsin2
  • Bragsin2 pictures
  • $33.00
  • 2026-09-10
  • CAS:342795-08-8
  • Purity: 99.87%
  • Supply Ability: 10g
  • Bragsin2
  • Bragsin2 pictures
  • $33.00
  • 2026-07-14
  • CAS:342795-08-8
  • Purity: 99.87%
  • Supply Ability: 10g
6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one Basic information
Product Name:6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one
Synonyms:6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one;Bragsin2;BRAGSIN2;BRAGSIN-2;BRAGSIN 2;Bragsin 2 NEW;4H-1-Benzopyran-4-one, 6-methoxy-5-nitro-2-(trifluoromethyl)-;Bragsin2,inhibit,Bragsin-2,Inhibitor;Bragsin2, 10 mM in DMSO;6-Methoxy-5-nitro-2-(trifluoromethyl)-4H-1-benzopyran-4-one
CAS:342795-08-8
MF:C11H6F3NO5
MW:289.16
EINECS:
Product Categories:
Mol File:342795-08-8.mol
6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one Structure
6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one Chemical Properties
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (345.83 mM; Need ultrasonic)
form Solid
color Off-white to light yellow
InChIKeyWJUILHMXVGFAIS-UHFFFAOYSA-N
SMILESFC(F)(F)c1[o]c2c([c](c1)=O)c(c(cc2)OC)[N+](=O)[O-]
Safety Information
WGK Germany WGK 3
Storage Class13 - Non Combustible Solids
MSDS Information
6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one Usage And Synthesis
UsesBragsin2 is a potent, selective and noncompetitive nucleotide exchange factor BRAG2 inhibitor, with an IC50 of 3 μM. Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer, leads BRAG2 unable to activate lipidated Arf GTPase. Bragsin2 affects breast cancer stem cells[1].
Biological ActivityBragsin2 is a hydration resistant cell penetrant, potent and selective noncompetitive inhibitor of ArfGEF BRAG2 (Afr guanine nucleotide exchange factor BRAG2) th at inhibits Arf GTPase activation in vitro and in cells. It binds to pleckstrin homology (PH) domain of BRAG2 and misposition BRAG2 on the membrane. Bragsin2 disrupt the function of the yeast ArfGEF Sec7p. Bragsin2 suppresses tumorsphere formation of some breast cancer stem cell lines including SUM149 and S68.
References[1] Nawrotek A, et al. PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling. Nat Chem Biol. 2019 Feb 11. doi: 10.1038/s41589-019-0228-3. DOI:10.1038/s41589-019-0228-3
6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one Preparation Products And Raw materials
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