1,3-DIMETHYL-1H-PYRAZOLE-4-CARBALDEHYDE manufacturers
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| | 1,3-DIMETHYL-1H-PYRAZOLE-4-CARBALDEHYDE Basic information |
| Product Name: | 1,3-DIMETHYL-1H-PYRAZOLE-4-CARBALDEHYDE | | Synonyms: | 1,3-dimethyl-1H-pyrazole-4-carbaldehyde(SALTDATA: FREE);ART-CHEM-BB B000370;AKOS PAO-0261;AKOS B000370;1,3-DIMETHYL-1H-PYRAZOLE-4-CARBALDEHYDE;TIMTEC-BB SBB000017;1,3-Dimethyl-1H-pyrazol-4-carbaldehyde;1,3-Dimethyl-4-formylpyrazole | | CAS: | 25016-12-0 | | MF: | C6H8N2O | | MW: | 124.14 | | EINECS: | | | Product Categories: | | | Mol File: | 25016-12-0.mol |  |
| | 1,3-DIMETHYL-1H-PYRAZOLE-4-CARBALDEHYDE Chemical Properties |
| Melting point | 50℃ | | Boiling point | 98-100℃ (760 Torr) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | Appearance | Off-white to light yellow Solid | | InChI | InChI=1S/C6H8N2O/c1-5-6(4-9)3-8(2)7-5/h3-4H,1-2H3 | | InChIKey | IGJREDVLGVEPFI-UHFFFAOYSA-N | | SMILES | N1(C)C=C(C=O)C(C)=N1 |
| Hazard Codes | Xi | | HazardClass | IRRITANT | | HS Code | 2933199090 |
| | 1,3-DIMETHYL-1H-PYRAZOLE-4-CARBALDEHYDE Usage And Synthesis |
| Uses | 1,3-Dimethyl-1H-pyrazole-4-carbaldehyde is used in preparation of the inhibitors of SARM1 for the treatment or preventing of axonal degeneration. | | Synthesis | GENERAL PROCEDURE: Phosphorus oxychloride (POCl3, 0.1 mol) was slowly added dropwise to N,N-dimethylformamide (DMF, 20 mL) at 0°C. The mixture was cooled to -20°C and N-alkylhydrazone (0.05 mol) was added dropwise to DMF (10 mL) at that temperature. After 1 hour of reaction, the mixture was cooled to -20 °C and a solution of N-alkylhydrazone (0.05 mol) in DMF (10 mL) was slowly added dropwise at this temperature. The reaction was kept at -20 °C with stirring for 3 h. The temperature was then increased to 80 °C with continued stirring for 2 h. The reaction was then carried out at -20 °C with stirring. After completion of the reaction, the mixture was cooled to room temperature and carefully poured into ice (100 g). The mixture was adjusted to alkaline (pH=9-10) with 30% aqueous sodium hydroxide solution. The product was extracted with chloroform (CHCl3, 3 x 200 mL). The organic phases were combined and dried over anhydrous sodium sulfate (Na2SO4). The solvent was removed by concentration under reduced pressure and the residue was purified by vacuum distillation. | | References | [1] Chemistry of Heterocyclic Compounds, 2011, vol. 47, # 8, p. 1048 - 1049
[2] Tetrahedron Letters, 2014, vol. 55, # 14, p. 2187 - 2189 |
| | 1,3-DIMETHYL-1H-PYRAZOLE-4-CARBALDEHYDE Preparation Products And Raw materials |
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