7-bromo-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one

Request For Quotation
7-bromo-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one Suppliers list
Company Name: TargetMol  
Tel: 400-821-0310 15002144251
Email: xuexiang.shao@tsbiochem.com
Company Name: RongNa Biotechnology Co.,Ltd  
Tel: +86-86-13583358881 +8618560316533
Email: Brad@rongnabiotech.com

7-bromo-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one manufacturers
7-bromo-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one Basic information
Product Name:7-bromo-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
Synonyms:7-bromo-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one;2H-1,4-Benzodiazepin-2-one, 7-bromo-1,3-dihydro-3-hydroxy-5-phenyl-;3-hydroxy Desalkylgidazepam
CAS:37891-18-2
MF:C15H11BrN2O2
MW:331.16
EINECS:202-303-5
Product Categories:
Mol File:37891-18-2.mol
7-bromo-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one Structure
7-bromo-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one Chemical Properties
Melting point 202-203 °C(Solv: ethanol (64-17-5))
Boiling point 517.6±50.0 °C(Predicted)
density 1.61±0.1 g/cm3(Predicted)
solubility DMSO: Soluble: =10 mg/ml
Ethanol: Slightly soluble: 0.1-1 mg/ml
pka10.94±0.70(Predicted)
Safety Information
MSDS Information
7-bromo-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one Usage And Synthesis
Uses3-Hydroxy desalkylgidazepam (compound 2) is the active metabolite of Gidazepam (HY-U00315) and Desalkylgidazepam (HY-W634748).
References[1] Pavlovsky V I, et al. Synthesis, Affinity for Central Benzodiazepine Receptors, and Hypnosedative and Anxiolytic Properties of 3-Acyloxy-5-Aryl-7-Bromo-1, 2-Dihydro-3 H-1, 4-Benzodiazepin-2-Ones[J]. Pharmaceutical Chemistry Journal, 2019, 53: 207-211.
[2] PETER D MASKELL  Kieran R M  Gemma Wilson. Designer Benzodiazepines Gidazepam and Desalkygidazepam (Bromonordiazepam): What Do We Know[J]. Journal of analytical toxicology, 2023, 47 4: 324-331. DOI: 10.1093/jat/bkad004
[3] G B KOLYVANOV. [Gidazepam biotransformation and pharmacokinetics in different species of animals and man].[J]. Eksperimental”naya i Klinicheskaya Farmakologiya, 1993, 56 3: 48-50.
[4] V. I. PAVLOVSKII. Synthesis and Analgesic Activity of 3-Arylamino-1,2-Dihydro-3H-1,4-Benzodiazepin-2-Ones[J]. Pharmaceutical Chemistry Journal, 2015, 32 1: 592-597. DOI: 10.1007/s11094-015-1335-4
7-bromo-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one Preparation Products And Raw materials
Tag:7-bromo-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one(37891-18-2) Related Product Information
Bromonordiazepam 7-bromo-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one 7-broMo-5-(2-fluoro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one Desalkylgidazepam-d5 α-hydroxy Flualprazolam 1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine