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| | (R)-2-Methylpyrrolidine hydrochloride Basic information |
| Product Name: | (R)-2-Methylpyrrolidine hydrochloride | | Synonyms: | Pyrrolidine, 2-methyl-, hydrochloride (1:1), (2R)-;(R)-2-METHYL-PYRROLIDINE, HCL;(R)-2-METHYLPYRROLIDINE HYDROCHLORIDE;(R)-2-METHYLPYRROLIDINE.HCL 98.0%;(2R)-2-methyl-Pyrrolidine hydrochloride (1:1);(R)-2-Methylpyrrolidinemonohydrochloride;(R)-2-Methylpyrrolidine hydrochloride - [M90991] | | CAS: | 135324-85-5 | | MF: | C5H12ClN | | MW: | 121.61 | | EINECS: | | | Product Categories: | Pyrrole&Pyrrolidine&Pyrroline | | Mol File: | 135324-85-5.mol |  |
| | (R)-2-Methylpyrrolidine hydrochloride Chemical Properties |
| Melting point | 73.0 to 77.0 °C | | storage temp. | Inert atmosphere,Room Temperature | | form | powder to crystaline | | color | White to Almost white | | Optical Rotation | Consistent with structure | | InChI | InChI=1/C5H11N.ClH/c1-5-3-2-4-6-5;/h5-6H,2-4H2,1H3;1H/t5-;/s3 | | InChIKey | JNEIFWYJFOEKIM-USHJBNIQNA-N | | SMILES | C[C@H]1NCCC1.Cl |&1:1,r| | | CAS DataBase Reference | 135324-85-5(CAS DataBase Reference) |
| | (R)-2-Methylpyrrolidine hydrochloride Usage And Synthesis |
| Synthesis | Step B: (i) Synthesis of (R)-2-methylpyrrolidine hydrochloride; (i) (R)-tert-butyl 2-methylpyrrolidine-1-carboxylate (22.7 g, 123 mmol) was dissolved in 4 M hydrogen chloride in dioxane solution (100 mL) and the reaction was stirred for 30 min at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio 2:1 ethyl acetate/hexane) to confirm complete consumption of the raw material. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was dissolved in a solvent mixture of acetonitrile and toluene and the solvent was again removed by distillation under reduced pressure. The resulting white solid was dried overnight under reduced pressure to give (R)-2-methylpyrrolidine hydrochloride (14.6 g) in 98% yield. The product was characterized by 1H NMR (400 MHz, CDCl3) with chemical shifts δ 1.55 (d, J = 6.57 Hz, 3H), 1.66-1.77 (m, 1H), 1.95-2.04 (m, 1H), 2.05-2.23 (m, 2H), 3.25-3.36 (m, 1H), 3.37-3.48 (m, 1H), and 3.62-3.74 (m, 1H), 9.38 (s, 1H), 9.86 (s, 1H). | | References | [1] Patent: WO2008/5338, 2008, A1. Location in patent: Page/Page column 80
[2] Tetrahedron, 2006, vol. 62, # 18, p. 4584 - 4589
[3] Patent: US2004/260100, 2004, A1. Location in patent: Page 8
[4] Patent: WO2006/19833, 2006, A1. Location in patent: Page/Page column 44
[5] Organic and Biomolecular Chemistry, 2010, vol. 8, # 20, p. 4533 - 4535 |
| | (R)-2-Methylpyrrolidine hydrochloride Preparation Products And Raw materials |
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