ME1
| 中文名称 | ME1 |
|---|---|
| 中文同义词 | 化合物 T11940;苹果酸酶抑制剂ME1,10 MM DMSO 溶液;苹果酸酶抑制剂ME1;3-(4-(4-羟基苯基)哌嗪-1-基)-1-苯基吡咯烷-2,5-二酮;Malic Enzyme inhibitor ME1 (ME1) |
| 英文名称 | 4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate |
| 英文同义词 | 4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate;Malic Enzyme inhibitor ME1;2,5-Pyrrolidinedione, 3-[4-(4-hydroxyphenyl)-1-piperazinyl]-1-phenyl-;Malic enzyme inhibitor ME1 (Synonyms: ME1);Malic enzyme inhibitor ME1, 10 mM in DMSO;3-(4-(4-Hydroxyphenyl)piperazin-1-yl)-1-phenylpyrrolidine-2,5-dione;Malic Enzyme inhibitor ME1 (ME1) |
| CAS号 | 522649-59-8 |
| 分子式 | C20H21N3O3 |
| 分子量 | 351.4 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 522649-59-8.mol |
| 结构式 |  |
ME1 性质
| 沸点 | 638.1±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.342±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：125 mg/mL（355.72 mM） |
| 形态 | 固体 |
| 酸度系数(pKa) | 12.18±0.30(Predicted) |
| 颜色 | 白色至米白色 |
Malic enzyme inhibitor ME1 (ME1; compound 1) 是一种有效的苹果酸酶 (ME1) 抑制剂，IC50 为 0.15 μM。
IC50: 0.15 μM (Malic enzyme)
Malic enzyme inhibitor ME1 (ME1; ME1*) (50 μM; 72 hours) shows a significant reduction in total cell numbers.
Malic enzyme inhibitor ME1 shows a significant reduction in cell viability/metabolic activity in MTS cell.
Malic enzyme inhibitor ME1 dose-dependently reduces the number of colonies formed by both HCT116 and HT29 cells.
Cell Viability Assay
| Cell Line: | HCT116 and HT29 cell line |
| Concentration: | 50 μM |
| Incubation Time: | 72 hours |
| Result: | Showed a significant reduction in total cell numbers. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-124861 | ME1 Malic enzyme inhibitor ME1 | 522649-59-8 | 1mg | 850元 |
| 2026/06/05 | HY-124861 | ME1 Malic enzyme inhibitor ME1 | 522649-59-8 | 5mg | 2550元 |