4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate

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4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate manufacturers
4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate Basic information
Product Name:4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate
Synonyms:4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate;Malic Enzyme inhibitor ME1;2,5-Pyrrolidinedione, 3-[4-(4-hydroxyphenyl)-1-piperazinyl]-1-phenyl-;Malic enzyme inhibitor ME1 (Synonyms: ME1);Malic enzyme inhibitor ME1, 10 mM in DMSO;3-(4-(4-Hydroxyphenyl)piperazin-1-yl)-1-phenylpyrrolidine-2,5-dione;Malic Enzyme inhibitor ME1 (ME1)
CAS:522649-59-8
MF:C20H21N3O3
MW:351.4
EINECS:
Product Categories:
Mol File:522649-59-8.mol
4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate Structure
4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate Chemical Properties
Boiling point 638.1±55.0 °C(Predicted)
density 1.342±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 125 mg/mL (355.72 mM)
form Solid
pka12.18±0.30(Predicted)
color White to off-white
Safety Information
MSDS Information
4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate Usage And Synthesis
UsesMalic enzyme inhibitor ME1 (ME1; compound 1) is a potent inhibitor of Malic enzyme (ME1) with an IC50 of 0.15 μM[1][2].
Biological ActivityMalic enzyme inhibitor ME1 (ME1; compound 1) is a potent malic enzyme (ME1) inhibitor with IC50 of 0.15 μM.
in vitro

Malic enzyme inhibitor ME1 (ME1; ME1*) (50 μM; 72 hours) shows a significant reduction in total cell numbers.
It shows a significant reduction in cell viability/metabolic activity in MTS cell.
It dose-dependently reduces the number of colonies formed by both HCT116 and HT29 cells.

Cell Viability Assay

Cell Line: HCT116 and HT29 cell line
Concentration: 50 μM
Incubation Time: 72 hours
Result: Showed a significant reduction in total cell numbers.
target

IC50: 0.15 μM (Malic enzyme)

References[1] Zhang YJ, et al. In silico design and synthesis of piperazine-1-pyrrolidine-2,5-dione scaffold-based novel malic enzyme inhibitors. Bioorg Med Chem Lett. 2006 Feb;16(3):525-8. Epub 2005 Nov 8. DOI:10.1016/j.bmcl.2005.10.065
[2] Fernandes L, et al. Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice. Sci Rep. 2018 Sep 24;8(1):14268. DOI:10.1038/s41598-018-32532-w
4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate Preparation Products And Raw materials
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