| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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400-9205774 400-920-5774 |
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sales@glpbio.cn |
| Products Intro: |
Product Name:C6 D-threo Ceramide (d18:1/6:0)
CAS:189894-79-9
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
SHANGHAI ZZBIO CO., LTD.
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18019219489 18901678489 |
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tech@zzbioco.com |
| Products Intro: |
Product Name:C6 D-threo Ceramide (d18:1/6:0)
CAS:189894-79-9
Package:1mg
|
| Company Name: |
Chengdu Peter-like Biotechnology Co., Ltd.
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028-81700200 13308200041 |
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2851167782@qq.com |
| Products Intro: |
Product Name:C6 D-threo Ceramide (d18:1/6:0)
CAS:189894-79-9
Purity:HPLC>=98% 现货 Package:5mg10mg20mg50mg100mg500mg1g2g等应客户需求包装
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| Company Name: |
Cayman Chemical Company
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| Tel: |
800-364-9897 |
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sales@caymanchem.com |
| Products Intro: |
Product Name:C6 D-threo Ceramide (d18:1/6:0)
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| | C6 D-threo Ceramide (d18:1/6:0) Basic information |
| Product Name: | C6 D-threo Ceramide (d18:1/6:0) | | Synonyms: | C6 D-threo Ceramide (d18:1/6:0);Hexanamide, N-[(1R,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-;N-[(1R,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-hexanamide | | CAS: | 189894-79-9 | | MF: | C24H47NO3 | | MW: | 397.63 | | EINECS: | | | Product Categories: | | | Mol File: | 189894-79-9.mol |  |
| | C6 D-threo Ceramide (d18:1/6:0) Chemical Properties |
| Boiling point | 574.7±50.0 °C(Predicted) | | density | 0.946±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | A solid | | pka | 13.53±0.20(Predicted) |
| | C6 D-threo Ceramide (d18:1/6:0) Usage And Synthesis |
| Description | C6 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 D-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlike C6 L-erythro ceramide , C6 D-threo ceramide cannot be converted to C6 glucosylceramide by ceramide glucosyltransferase. C6 D-threo Ceramide promotes survival of isolated rat spinal neurons when used at concentrations up to 2.5 μM but induces cell death at concentrations greater than 5 μM. It enhances IL-4 production induced by phorbol 12-myristate 13-acetate (PMA; ) in EL4 T cells when used at a concentration of 10 μM. [Matreya, LLC. Catalog No. 1809] | | Uses | C6 D-Threo Ceramide (d18:1/6:0) is a bioactive sphingolipid and cell-permeable analog of ceramides. C6 D-Threo Ceramide (d18:1/6:0) enhances IL-4 production induced by Phorbol 12-myristate 13-acetate (HY-18739) in EL4 T cells[1][2]. | | IC 50 | IL-4 | | References | [1] Park J, et al. Inhibitory activity of a ceramide library on interleukin-4 production from activated T cells. Bioorg Med Chem. 2005 Apr 1;13(7):2589-95. DOI:10.1016/j.bmc.2005.01.027
[2] Irie F, et al. Application of exogenous ceramide to cultured rat spinal motoneurons promotes survival or death by regulation of apoptosis depending on its concentrations. J Neurosci Res. 1998 Nov 15;54(4):475-85. DOI:10.1002/(SICI)1097-4547(19981115)54:4<475::AID-JNR5>3.0.CO;2-P |
| | C6 D-threo Ceramide (d18:1/6:0) Preparation Products And Raw materials |
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