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Shanghai Hongye Biotechnology Co. Ltd
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Product Name:C8 D-threo Ceramide (d18:1/8:0)
CAS:175892-43-0
Purity:>98% Package:1mg;10mg;50mg;100mg;
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
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Product Name:C8 D-threo Ceramide (d18:1/8:0)
CAS:175892-43-0
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627 |
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customer_service@efebio.com |
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Product Name:C8 D-threo Ceramide (d18:1/8:0)
CAS:175892-43-0
Purity:98% Package:1mg
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SHANGHAI ZZBIO CO., LTD.
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18019219489 18901678489 |
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Product Name:C8 D-threo Ceramide (d18:1/8:0)
CAS:175892-43-0
Package:1mg
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Cayman Chemical Company
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800-364-9897 |
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sales@caymanchem.com |
| Products Intro: |
Product Name:C8 D-threo Ceramide (d18:1/8:0)
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| | C8 D-threo Ceramide (d18:1/8:0) Basic information |
| Product Name: | C8 D-threo Ceramide (d18:1/8:0) | | Synonyms: | C8 D-threo Ceramide (d18:1/8:0);Octanamide, N-[(1R,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-;N-[(1R,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-octanamide | | CAS: | 175892-43-0 | | MF: | C26H51NO3 | | MW: | 425.69 | | EINECS: | | | Product Categories: | | | Mol File: | 175892-43-0.mol |  |
| | C8 D-threo Ceramide (d18:1/8:0) Chemical Properties |
| Boiling point | 595.5±50.0 °C(Predicted) | | density | 0.939±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Chloroform: Soluble; DMF: Soluble; DMSO: Soluble; Ethanol: Soluble | | form | A solid | | pka | 13.54±0.20(Predicted) |
| | C8 D-threo Ceramide (d18:1/8:0) Usage And Synthesis |
| Description | C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.1 It is cytotoxic to U937 cells (IC50 = 17 μM) and induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 ceramide .1,2 C8 D-threo Ceramide is a substrate for E. coli diacylglycerol kinase.1 It activates ceramide-activated protein kinase (CAPK) in U937 cells. C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein release, with a 50% release dose (RD50) value of ~5 μg/ml.3 | | Uses | C8 D-threo Ceramide (d18:1/8:0) is a sphingolipid analog that can effectively induce apoptosis in U937 cells and cause fragmentation of nucleosomal DNA[1]. | | References | 1. Karasavvas, N., Erukulla, R.K., Bittman, R., et al. Stereospecific induction of apoptosis in U937 cells by N-octanoyl-sphingosine stereoisomers and N-octyl-sphingosine. The ceramide amide group is not required for apoptosis Eur. J. Biochem. 236(2),729-737(1996).
2. Chang, Y.-T., Choi, J., Ding, S., et al. The synthesis and biological characterization of a ceramide library J. Am. Chem. Soc. 124(9),1856-1857(2002).
3. Zitzer, A., Bittman, R., Verbicky, C.A., et al. Coupling of cholesterol and cone-shaped lipids in bilayers augments membrane permeabilization by the cholesterol-specific toxins streptolysin O and Vibrio cholerae cytolysin J. Biol. Chem. 276(18),14628-14633(2001). |
| | C8 D-threo Ceramide (d18:1/8:0) Preparation Products And Raw materials |
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