Neuropeptide Y (13-36) (human, rat) (trifluoroacetate salt)

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Neuropeptide Y (13-36) (human, rat) (trifluoroacetate salt) Basic information
Product Name:Neuropeptide Y (13-36) (human, rat) (trifluoroacetate salt)
Synonyms:Neuropeptide Y (13-36) (human, rat) (trifluoroacetate salt)
CAS:
MF:C136H208F3N41O38S
MW:3114.4188296
EINECS:
Product Categories:
Mol File:Mol File
Neuropeptide Y (13-36) (human, rat) (trifluoroacetate salt) Structure
Neuropeptide Y (13-36) (human, rat) (trifluoroacetate salt) Chemical Properties
solubility Water: 1 mg/ml
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MSDS Information
Neuropeptide Y (13-36) (human, rat) (trifluoroacetate salt) Usage And Synthesis
DescriptionNeuropeptide Y (NPY) (13-36) is a C-terminal fragment of NPY, a neuropeptide involved in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion.1 NPY (13-36) is an agonist of the NPY receptor Y2 with Ki values of 1.28 and 2.62 nM for the rat recombinant receptor in CHO cells and in rat jejunal crypt cell membranes, respectively.2 It inhibits forskolin-induced cAMP accumulation with EC50 values of 300, 2.2, >1,000, and 20 at Y1, Y2, Y4, and Y5 receptors, respectively, in vitro .3 NPY (13-36) inhibits basal short circuit currents (EC50 = ~2 µM) and electrical field stimulated-secretory responses in isolated rat jejunal mucosa (EC50 = ~200 nM) but does so less potently than NPY (Item Nos. 24716 | 15071).4 NPY (13-36) also reduces the frequency of spontaneous excitatory postsynaptic currents (EPSCs) in the CA3 region of hippocampal slices from wild-type but not Y5 receptor knockout mice.5WARNING This product is not for human or veterinary use.
References[1] BALASUBRAMANIAM A. Neuropeptide Y Family of Hormones: Receptor Subtypes and Antagonists[J]. Peptides, 1997, 18 3: Pages 445-457. DOI: 10.1016/s0196-9781(96)00347-6
[2] M. GOUMAIN. The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning.[J]. Molecular Pharmacology, 2001, 60 1 1: 124-134. DOI: 10.1124/mol.60.1.124
[3] CHRISTOPHE GERALD. A receptor subtype involved in neuropeptide-Y-induced food intake[J]. Nature, 1996, 382 6587: 168-171. DOI: 10.1038/382168a0
[4] H.M. COX  A. W C. The effects of neuropeptide Y and its fragments upon basal and electrically stimulated ion secretion in rat jejunum mucosa[J]. British Journal of Pharmacology, 1990, 101 2: 247-252. DOI: 10.1111/j.1476-5381.1990.tb12695.x
[5] HUIFU GUO. Y5 receptors mediate neuropeptide Y actions at excitatory synapses in area CA3 of the mouse hippocampus.[J]. Journal of neurophysiology, 2002, 87 1 1: 558-566. DOI: 10.1152/jn.00532.2001
Neuropeptide Y (13-36) (human, rat) (trifluoroacetate salt) Preparation Products And Raw materials
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