[Leu31,Pro34] Neuropeptide Y (human) (trifluoroacetate salt)

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[Leu31,Pro34] Neuropeptide Y (human) (trifluoroacetate salt) Basic information
Product Name:[Leu31,Pro34] Neuropeptide Y (human) (trifluoroacetate salt)
Synonyms:[Leu31,Pro34] Neuropeptide Y (human) (trifluoroacetate salt)
CAS:
MF:C191H285F3N54O58S
MW:4354.6938096
EINECS:
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Mol File:Mol File
[Leu31,Pro34] Neuropeptide Y (human) (trifluoroacetate salt) Structure
[Leu31,Pro34] Neuropeptide Y (human) (trifluoroacetate salt) Chemical Properties
solubility Water: 1 mg/ml
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MSDS Information
[Leu31,Pro34] Neuropeptide Y (human) (trifluoroacetate salt) Usage And Synthesis
Description[Leu31,Pro34] Neuropeptide Y (NPY) is an agonist of the NPY receptors Y1 and Y5 with Ki values of 0.11 and 0.17 nM, respectively, for human and 0.08 and 0.18 nM, respectively, for rhesus monkey receptors.1 It reduces forskolin-induced cAMP accumulation in L-M(TK-) cells expressing human and rat Y4 receptors (EC50s = 29.5 and 2.95 nM, respectively). 2 It also binds to rhesus monkey Y2 and mouse Y6 receptors (Kis = 410 and 9.7 nM, respectively).1,3 In vitro, [Leu31,Pro34] NPY increases cellular protein mass by 25% in rat ventricular cardiomyocytes when used at a concentration of 10 nM.4 In vivo, [Leu31,Pro34] NPY (0.7-7 nmol, i.c.v.) increases food intake in rats.5WARNING This product is not for human or veterinary use.
References[1] DONALD R. GEHLERT . Cloning and characterization of Rhesus monkey neuropeptide Y receptor subtypes1[J]. Peptides, 2001, 22 3: Pages 343-350. DOI: 10.1016/s0196-9781(01)00336-9
[2] MARY W WALKER . A Structure-Activity Analysis of the Cloned Rat and Human Y4 Receptors for Pancreatic Polypeptide1[J]. Peptides, 1997, 18 4: Pages 609-612. DOI: 10.1016/s0196-9781(97)00070-3
[3] DEBORRA E MULLINS. Pharmacological characterization of the cloned neuropeptide Y y6 receptor[J]. European journal of pharmacology, 2000, 395 2: Pages 87-93. DOI: 10.1016/s0014-2999(00)00255-7
[4] SUZANNE M NICHOLL. Neuropeptide Y Y1 receptor regulates protein turnover and constitutive gene expression in hypertrophying cardiomyocytes[J]. European journal of pharmacology, 2002, 441 1: Pages 23-34. DOI: 10.1016/s0014-2999(02)01440-1
[5] ANDREA C HAYNES . Characterisation of the neuropeptide Y receptor that mediates feeding in the rat: a role for the Y5 receptor[J]. Regulatory Peptides, 1998, 75: Pages 355-361. DOI: 10.1016/s0167-0115(98)00088-3
[Leu31,Pro34] Neuropeptide Y (human) (trifluoroacetate salt) Preparation Products And Raw materials
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