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5-OxoETE methyl ester manufacturers
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| | 5-OxoETE methyl ester Basic information |
| Product Name: | 5-OxoETE methyl ester | | Synonyms: | 5-OxoETE methyl ester;5 OxoETE methyl ester,5OxoETE methyl ester;6,8,11,14-Eicosatetraenoic acid, 5-oxo-, methyl ester, (6E,8Z,11Z,14Z)- | | CAS: | 74785-00-5 | | MF: | C21H32O3 | | MW: | 332.48 | | EINECS: | | | Product Categories: | | | Mol File: | 74785-00-5.mol |  |
| | 5-OxoETE methyl ester Chemical Properties |
| Boiling point | 453.3±45.0 °C(Predicted) | | density | 0.949±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | 0.1 M Na2CO3: 2 mg/ml; DMF: miscible; DMSO: miscible; Ethanol: miscible; PBS (pH 7.2): 0.8 mg/ml |
| | 5-OxoETE methyl ester Usage And Synthesis |
| Description | 5-OxoETE methyl ester is an esterified form of the polyunsaturated keto acid 5-oxoETE . 5-OxoETE methyl ester is an agonist of oxoeicosanoid receptor 1 (OXER1; EC50 = 1.54 μM for β-arrestin recruitment) that has a higher maximal response than 5-oxoETE in a β-arrestin assay.1 | | Uses | 5-OxoETE methyl ester is the agonist for oxoeicosanoid receptor 1 (OXER1). 5-OxoETE methyl ester binds to OXER1, and activates downstream signaling pathways β-arrestin recruitment with an EC50 of 1.54 μM[1]. | | References | 1. Stepniewski, T.M., Torrens-Fontanals, M., Rodríguez-Espigares, I., et al. Synthesis, molecular modelling studies and biological evaluation of new oxoeicosanoid receptor 1 agonists Bioorg. Med. Chem. 26(12),3580-3587(2018). |
| | 5-OxoETE methyl ester Preparation Products And Raw materials |
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