| Company Name: |
InvivoChem |
| Tel: |
13549236410 |
| Email: |
sales@invivochem.cn |
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| | Compound 919278 Basic information |
| Product Name: | Compound 919278 | | Synonyms: | Compound 919278;LTβR-IN-1;LTβR IN 1,LTβRIN1;2H-Isoindole-2-acetamide, N-1H-benzimidazol-2-yl-1,3-dihydro-α-methyl-1-oxo-, (αR)-;LTβR-IN-1, 10 mM in DMSO;LTβR-IN-1 | | CAS: | 2189366-77-4 | | MF: | C18H16N4O2 | | MW: | 320.35 | | EINECS: | | | Product Categories: | | | Mol File: | 2189366-77-4.mol |  |
| | Compound 919278 Chemical Properties |
| density | 1.424±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 125 mg/mL (390.20 mM; Need ultrasonic) | | form | Solid | | pka | 10.68±0.10(Predicted) | | color | White to off-white |
| | Compound 919278 Usage And Synthesis |
| Uses | LTβR-IN-1 is a potent, selective lymphotoxin β receptor (LTβR) inhibitor. LTβR-IN-1 also selectively inhibits the nuclear translocation of p52 depended on TNF12A, instead of the nuclear translocation of p65 mediated by TNF-α receptor. LTβR-IN-1 regulates the NF-kB signaling pathway IN a ligand-independent manner[1]. | | Biological Activity | LTβR-IN-1 is a potent, selective lymphotoxin β receptor (LTβR) inhibitor with an IC50 of 10 μM. LTβR-IN-1 is potent in TWEAK-stimulated p52 translocation assays with an IC50 of 10 μM and did not alter TNF-α-induced p65 nuclear translocation[1]. | | References | [1]. Henry KL, et al. CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling. Sci Signal. 2018 Jul 31;11(541). |
| | Compound 919278 Preparation Products And Raw materials |
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