| Company Name: |
ChemShuttle, Inc. |
| Tel: |
0510-83588313-811 18800520310 |
| Email: |
sales@chemshuttle.com |
| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
PBD-150 manufacturers
- PBD-150
-
- $35.00
-
2026-04-22
- CAS:790663-33-1
- Purity: 99.68%
- Supply Ability: 10g
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| | PBD-150 Basic information |
| Product Name: | PBD-150 | | Synonyms: | PBD-150;1-(3-(1H-imidazol-1-yl)propyl)-3-(3,4-dimethoxyphenyl)thiourea;Inhibitor,Amyloid-β,PBD150,Abeta,PBD-150,β-amyloid peptide,inhibit,PBD 150,Alzheimer;Thiourea, N-(3,4-dimethoxyphenyl)-N'-[3-(1H-imidazol-1-yl)propyl]-;PBD-150, 10 mM in DMSO;PBD-150 ，S0529 | | CAS: | 790663-33-1 | | MF: | C15H20N4O2S | | MW: | 320.41 | | EINECS: | | | Product Categories: | | | Mol File: | 790663-33-1.mol |  |
| | PBD-150 Chemical Properties |
| Melting point | 160.0-161.0 °C(Solv: ethanol (64-17-5)) | | Boiling point | 502.7±60.0 °C(Predicted) | | density | 1.22±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (25 mg/ml) or ethanol (25 mg/ml) | | form | solid | | pka | 12.29±0.70(Predicted) | | color | White | | Stability: | Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| | PBD-150 Usage And Synthesis |
| Description | PBD-150 (790663-33-1) is an inhibitor of human glutaminyl cyclase (IC50 = 60 nM).1 PBD-150 diminished Ab plaque formation and gliosis while improving memory in a mouse model with small amounts of Ab3(pE)-40/42.2 | | Uses | PBD-150 is a human glutaminyl cyclase (hQC) Y115E-Y117E variant inhibitor, with a Ki value of 490 nM[1][2]. | | in vivo | PBD-150 is able to reduce the deposition of pyroglutamate-modified amyloid-β peptides in brain of transgenic mouse models of Alzheimer disease, leading to a significant improvement of learning and memory in those transgenic animals[3]. | | References | [1] MIRKO BUCHHOLZ. The First Potent Inhibitors for Human Glutaminyl Cyclase: Synthesis and Structure−Activity Relationship[J]. Journal of Medicinal Chemistry, 2005, 49 2: 664-677. DOI:10.1021/jm050756e
[2] STEPHAN SCHILLING. Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer”s disease–like pathology[J]. Nature Medicine, 2008, 14 10: 1106-1111. DOI:10.1038/nm.1872 |
| | PBD-150 Preparation Products And Raw materials |
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