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cjbscvictory |
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13348960310 13348960310 |
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RO-5963 manufacturers
- RO-5963
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- $64.00
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2026-07-27
- CAS:1416663-77-8
- Purity: 99.36%
- Supply Ability: 10g
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| | RO-5963 Basic information |
| Product Name: | RO-5963 | | Synonyms: | RO-5963;RO5963,RO 5963;1-Imidazolidineacetamide, 4-[(6-chloro-7-methyl-1H-indol-3-yl)methylene]-α-(3,4-difluorophenyl)-N-[2-hydroxy-1-(hydroxymethyl)ethyl]-2,5-dioxo-;RO-5963, 10 mM in DMSO | | CAS: | 1416663-77-8 | | MF: | C24H21ClF2N4O5 | | MW: | 518.9 | | EINECS: | | | Product Categories: | | | Mol File: | 1416663-77-8.mol |  |
| | RO-5963 Chemical Properties |
| density | 1.562±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 7.71±0.20(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | RO-5963 Usage And Synthesis |
| Description | RO-5963 is an inhibitor of the interaction of both MDM2 and MDMX with p53. | | Uses | RO-5963 is a dual p53-MDM2 and p53-MDMX inhibitor with IC50s of ~17 nM and ~24 nM, respectively[1]. | | References | [1] Graves B, et al. Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11788-93. DOI:10.1073/pnas.1203789109 |
| | RO-5963 Preparation Products And Raw materials |
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