| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
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| Product Name: | GC 14 | | Synonyms: | GC 14;Acetic acid, 2-[4-[[6-hydroxy-5-(1-methylethyl)-4'-nitro[1,1'-biphenyl]-3-yl]methyl]-3,5-dimethylphenoxy]- | | CAS: | 447415-34-1 | | MF: | C26H27NO6 | | MW: | 449.5 | | EINECS: | | | Product Categories: | | | Mol File: | 447415-34-1.mol |  |
| | GC 14 Chemical Properties |
| Boiling point | 632.4±55.0 °C(Predicted) | | density | 1.241±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 3.15±0.10(Predicted) |
| | GC 14 Usage And Synthesis |
| Description | GC 14 is a thyroid hormone antagonist. GC 14 contains extensions at the 5′-position of the outer thyronine ring or from the bridging carbon and has only a modest affinity and potency for the thyroid hormone receptor (TR) that limits studies of their antagonistic actions[2]. | | Uses | GC 14 is a selective thyroid hormone receptor antagonist, with IC50 values of 35 nM and 200 nM for hTRβ and hTRα, respectively. | | References | [1]. Chiellini G, et al. Synthesis and biological activity of novel thyroid hormone analogues: 5'-aryl substituted GC-1 derivatives. Bioorg Med Chem. 2002 Feb;10(2):333-46. [2]. Nguyen NH, et al. Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. J Med Chem. 2002 Jul 18;45(15):3310-20. |
| | GC 14 Preparation Products And Raw materials |
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