N1-(4-Chlorophenyl)benzene-1,2-diamine

N1-(4-Chlorophenyl)benzene-1,2-diamine Suppliers list

Company Name:	Shanghai Baisley Pharmaceutical Technology Co., Ltd. Gold
Tel:	021-15995002467 15995002467
Email:	chen_shuming@126.com

N1-(4-Chlorophenyl)benzene-1,2-diamine manufacturers

N1-(4-Chlorophenyl)benzene-1,2-diamine Basic information

Product Name:	N1-(4-Chlorophenyl)benzene-1,2-diamine
Synonyms:	2-AMINO-4'-CHLORODIPHENYLAMINE;TIMTEC-BB SBB003366;N-(4-CHLOROPHENYL)-1,2-PHENYLENEDIAMINE;N-(4-chlorophenyl)benzene-1,2-diamine;(2-aminophenyl)(4-chlorophenyl)amine(SALTDATA: FREE);1,2-Benzenediamine, N-(4-chlorophenyl)-;N1-(4-Chlorophenyl)benzene-1,2-diaMine;N1-(4-Chlorophenyl)-2-amino-aniline
CAS:	68817-71-0
MF:	C12H11ClN2
MW:	218.68
EINECS:	272-391-8
Product Categories:
Mol File:	68817-71-0.mol

N1-(4-Chlorophenyl)benzene-1,2-diamine Chemical Properties

Melting point	117-119 °C(lit.)
Boiling point	357.0±27.0 °C(Predicted)
density	1.288±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	4.90±0.10(Predicted)
Appearance	Brown to reddish brown Solid
InChI	InChI=1S/C12H11ClN2/c13-9-5-7-10(8-6-9)15-12-4-2-1-3-11(12)14/h1-8,15H,14H2
InChIKey	WEUBIWJPIRTWDF-UHFFFAOYSA-N
SMILES	C1(NC2=CC=C(Cl)C=C2)=CC=CC=C1N

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English

N1-(4-Chlorophenyl)benzene-1,2-diamine Usage And Synthesis

Uses	N-(4-Chlorophenyl)-1,2-phenylenediamine is a reagent in the synthesis of clofazimine analogs as antileishmanials and antiplasmodials.
Uses	N-(4-Chlorophenyl)-1,2-phenylenediamine (2-Amino-4′-chlorodiphenylamine) was used in preparation of N-(p-chloro)phenylbenzimidazolin-2-one and monoaminophenazine dyes.
Synthesis	To a mixture of EtOH (100 ml) and NH4C1 saturated solution (15 ml), N-(4-chlorophenyl)-2-nitrobenzenamine (5.0 g, 20.1 mmol) was added, followed by iron powder (4.0 g). The reaction mixture was heated at 70 °C for 2h. The solid was filtered, and the filtrate was extracted by EA (100 mL x 3) and dried over Na2S04. After the solvent was removed, the mixture was purified by Combi-flash (PE: EA = 5 : 1) to give N1-(4-Chlorophenyl)benzene-1,2-diamine (4.1 g, 93.2 percent) as a light yellow solid.
References	[1] Chinese Journal of Chemistry, 2013, vol. 31, # 12, p. 1473 - 1482 [2] Organic Process Research and Development, 2016, vol. 20, # 2, p. 452 - 464 [3] Patent: WO2012/151512, 2012, A2. Location in patent: Page/Page column 103-104 [4] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 2, p. 145 - 150 [5] Patent: CN107445845, 2017, A. Location in patent: Paragraph 0047; 0048; 0049; 0050; 0051; 0052

N1-(4-Chlorophenyl)benzene-1,2-diamine Preparation Products And Raw materials

Raw materials	2-Phenazinamine, 5-(4-chlorophenyl)-3-[(4-chlorophenyl)imino]-3,5-dihydro--->Water-->Ammonium chloride-->N-(4-Chlorophenyl)-2-nitrobenzenamine-->Iron-->Ethanol
Preparation Products	N1-(4-chlorophenyl)-N2-(5-fluoro-2,4-dinitrophenyl)benzene-1,2-diamine

Tag:N1-(4-Chlorophenyl)benzene-1,2-diamine(68817-71-0) Related Product Information

Clofazimine, [methyl-3H] 1-(4-Chlorophenyl)-3-hydroxy-1,2-dihydroquinoxalin-2-one N-(4-Chlorophenyl)-2-nitrobenzenamine 4-Chlorodiphenylamine 5-Amino-2-chloro-10H-acridin-9-one 4-Amino-4'-chlorodiphenylamine-2-sulphonic acid 2-Amino-4-chlorodiphenylamine 2-Amino-4-chlorodiphenylamine Clofazimine o-Phenylenediamine 4-amino-4'-chlorodiphenylamine-2-sulfonic acid 2-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine N1-(4-Chlorophenyl)benzene-1,2-diamine