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BOC Sciences |
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1-631-485-4226; 16314854226 |
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info@bocsci.com |
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cjbscvictory |
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GNE-8505 manufacturers
- GNE-8505
-
- $1790.00
-
2026-05-11
- CAS:1620573-48-9
- Purity:
- Supply Ability: 10g
- GNE-8505
-
- $1790.00
-
2025-07-23
- CAS:1620573-48-9
- Purity:
- Supply Ability: 10g
|
| | GNE-8505 Basic information |
| Product Name: | GNE-8505 | | Synonyms: | GNE-8505;5-(1-(cyclopropylmethyl)-5-(3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl)-1H-pyrazol-3-yl)-3-(trifluoromethyl)pyridin-2-amine;GNE8505,GNE 8505;2-Pyridinamine, 5-[1-(cyclopropylmethyl)-5-[(1α,5α,6α)-3-(3-oxetanyl)-3-azabicyclo[3.1.0]hex-6-yl]-1H-pyrazol-3-yl]-3-(trifluoromethyl)- | | CAS: | 1620573-48-9 | | MF: | C21H24F3N5O | | MW: | 419.44 | | EINECS: | | | Product Categories: | | | Mol File: | 1620573-48-9.mol |  |
| | GNE-8505 Chemical Properties |
| Melting point | 198.6-200 °C | | Boiling point | 552.3±50.0 °C(Predicted) | | density | 1.69±0.1 g/cm3(Predicted) | | pka | 8.30±0.40(Predicted) | | form | Solid | | color | White to off-white |
| | GNE-8505 Usage And Synthesis |
| Description | GNE-8505 is a DLK inhibitor (IC50 = 10nM). | | Uses | GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK)[1]. | | References | [1] Le Pichon CE, et al. Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease. Sci Transl Med. 2017 Aug 16;9(403). pii: eaag0394. DOI:10.1126/scitranslmed.aag0394 |
| | GNE-8505 Preparation Products And Raw materials |
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