291778-77-3
| 中文名称 | 291778-77-3 |
|---|---|
| 中文同义词 | 化合物 T10254 |
| 英文名称 | AE-3763 |
| 英文同义词 | AE-3763;1-Imidazolidineacetic acid, 3-[2-[[(1S)-2-methyl-1-[[(2S)-2-[[[(1S)-3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]amino]carbonyl]-1-pyrrolidinyl]carbonyl]propyl]amino]-2-oxoethyl]-2-oxo-;2-(3-(2-(((S)-3-methyl-1-oxo-1-((S)-2-(((S)-1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl)carbamoyl)pyrrolidin-1-yl)butan-2-yl)amino)-2-oxoethyl)-2-oxoimidazolidin-1-yl)acetic acid |
| CAS号 | 291778-77-3 |
| 分子式 | C23H34F3N5O7 |
| 分子量 | 549.54 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 291778-77-3.mol |
| 结构式 |  |
291778-77-3 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
IC50: 29 nM (Human neutrophil elastase)
AE-3763 exhibits potent in vitro inhibitory activity against human neutrophil elastase as well as extremely high solubility and stability in water.
Edema and leukocytes infiltration into the lung are significantly inhibited by infusion of AE-3763. AE3763 significantly improves survival rate by 24 h in a mouse model of fatal shock associated with multiple organ dysfunction. AE-3763 dose-dependently prevents hemorrhage when given intravenously by infusion (ED 50 : 0.42 mg/kg/h) or by bolus injection (1.2 mg/kg). With regard to the toxicity of AE-3763 in mice, the results of a preliminary study have shown no overt toxic effect even at the high dose of 300 mg/kg, iv.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-19406 | AE-3763 | 291778-77-3 | 1 mg | 1450元 |
| 2026/09/15 | HY-19406 | 291778-77-3 AE-3763 | 291778-77-3 | 5mg | 3650元 |