(+/-)-BAY K 8644

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(+/-)-BAY K 8644 Basic information
Product Name:(+/-)-BAY K 8644
Synonyms:1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[2'-(TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER;1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[2-(TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID, METHYL ESTER;1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-[TRIFLUOROMETHYL]PHENYL)PYRIDINE-3-CARBOXYLIC ACID METHYL ESTER;(+/-)-BAY K 8644;BAY K-8644 (+/-);(+)-(S)-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)pyridine-5-carboxylic acid;(±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem
CAS:93468-89-4
MF:C16H15F3N2O4
MW:356.3
EINECS:
Product Categories:
Mol File:93468-89-4.mol
(+/-)-BAY K 8644 Structure
(+/-)-BAY K 8644 Chemical Properties
Melting point 166-172 °C
storage temp. 2-8°C
solubility DMSO: 184 mg/mL
form Yellow solid
Safety Information
Hazard Codes Xi
Risk Statements 36/38
Safety Statements 26-36
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
(+/-)-BAY K 8644 Usage And Synthesis
DefinitionChEBI: Methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate is a pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6. It is a dihydropyridine, a methyl ester, a C-nitro compound and a member of (trifluoromethyl)benzenes.
General DescriptionSynthetic dihydropyridine derivative that acts as an active Ca2+ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca2+ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive inotropic, and Ca2+ agonistic properties, whereas the (+)-enantiomer has weakly vasodilating, negative inotropic, and Ca2+ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.
Biochem/physiol ActionsPrimary TargetL-type Ca2+ channel
(+/-)-BAY K 8644 Preparation Products And Raw materials
Tag:(+/-)-BAY K 8644(93468-89-4) Related Product Information
(+/-) CAGED BAY K 8644 R(+)-BAY K 8644, CALCIUM CHANNEL R(+)-BAY K 8644,R(+)-BAY K 8644 CA2(+) CHANNEL BLOCKE,(+/-)-BAY K 8644, 0 TO 5 °C,R(+)-BAY K 8644 98% 0 C S(-)-BAY K 8644,S(-)-BAY K 8644 CA2+ CHANNEL ACTIVATO R(+)-BAY K 8644 CALCIUM CHANNEL (RS)-BAY K 8644,(+/-)-BAY K 8644,BAY K-8644 (+/-),(+/-)-BAY K8644 CALCIUM SLOW CHANNEL (+-)-CAGED BAY K 8644