S(-)-BAY K 8644

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S(-)-BAY K 8644 Basic information
Product Name:S(-)-BAY K 8644
Synonyms:S(-)-BAY K 8644;(4S)-1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[(2-TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER;S(-)-BAY K 8644 CA2+ CHANNEL ACTIVATO;(4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethyl)phenyl)-3-pyridinecarboxylicacidmethylester;s-(-)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester;[4S,(-)]-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethylphenyl)pyridine-3-carboxylic acid methyl ester;BAY-r-5417;R-5417
CAS:98625-26-4
MF:C16H15F3N2O4
MW:356.3
EINECS:
Product Categories:Calcium channel
Mol File:98625-26-4.mol
S(-)-BAY K 8644 Structure
S(-)-BAY K 8644 Chemical Properties
storage temp. 2-8°C
solubility H2O: slightly soluble
form solid
color yellow
Water Solubility H2O: slightly soluble
ethanol: soluble (Organic solutions are stable for at least 20 days at RT.)
InChI1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3/t13-/m0/s1
InChIKeyZFLWDHHVRRZMEI-ZDUSSCGKSA-N
SMILESCOC(=O)C1=C(C)NC(C)=C([C@H]1c2ccccc2C(F)(F)F)[N+]([O-])=O
Safety Information
Hazard Codes Xi
Risk Statements 36/38
Safety Statements 26-36
WGK Germany 3
HS Code 2933399990
Storage Class11 - Combustible Solids
Hazard ClassificationsEye Irrit. 2
Skin Irrit. 2
MSDS Information
ProviderLanguage
SigmaAldrich English
S(-)-BAY K 8644 Usage And Synthesis
Uses(S)-(-)-Bay K8644 has been used as a L-type calcium channel (LTCC) agonist in the suprachiasmatic nucleus (SCN) slices. It has also been used as a LTCC agonist to induce arrhythmiain rats.
DefinitionChEBI: (S)-Bay-K-8644 is a methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate in which the 4-position has (S)-configuration. It is an enantiomer of a (R)-Bay-K-8644.
General Description(S)-(-)-Bay K8644, a dihydropyridine compound is a Ca2+channel activator. It is an enantiomer of Bay K 8644.
Biological ActivityL-type Ca 2+ -channel activator with positive inotropic, vasoconstrictive and behavioral effects in vivo . Enantiomer of (1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester ).
Biochem/physiol Actions(S)-(-)-Bay K8644 enhances Ca2+ current, whereas the (+)-Bay K 8644 is a weak Ca2+ channel antagonist. Bay K 8644 is lipophilic and it effectively scavenges superoxide anions.
storageStore at +4°C
S(-)-BAY K 8644 Preparation Products And Raw materials
Tag:S(-)-BAY K 8644(98625-26-4) Related Product Information
3-[o-(alpha,alpha,alpha-trifluorotolyl)]propionic acid Phenibut 2-methyl-1-nitropropane 3-(2-Trifluoromethyl-phenyl)-propionaldehyde 3-(2-Trifluoromethyl-phenyl)-propan-1-ol 1-Nitro-2-methyl-butane Methyl 4-nitrobutyrate 4-Amino-3-phenyl-1-butanol 3-[(2-Trifluoromethyl)phenyl]-1-propene o-(trifluoromethyl)phenethylamine S(-)-BAY K 8644 BAY K-8644 (+/-),(+/-)-BAY K 8644,(RS)-BAY K 8644,(+/-)-BAY K8644 CALCIUM SLOW CHANNEL R(+)-BAY K 8644 CA2(+) CHANNEL BLOCKE,(+/-)-BAY K 8644, 0 TO 5 °C,R(+)-BAY K 8644 98% 0 C,R(+)-BAY K 8644 BAY K-8644 (+/-),(+/-)-BAY K 8644 beta-(Nitromethyl)-benzenepropanoic acid Methyl (R)-3-phenylbutyrate (+/-) CAGED BAY K 8644 R(+)-BAY K 8644, CALCIUM CHANNEL