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| | PROTX I Basic information |
| | PROTX I Chemical Properties |
| storage temp. | Store at -20°C | | form | Powder | | Water Solubility | Soluble to 2 mg/ml in water | | Sequence | Glu-Cys-Arg-Tyr-Trp-Leu-Gly-Gly-Cys-Ser-Ala-Gly-Gln-Thr-Cys-Cys-Lys-His-Leu-Val-Cys-Ser-Arg-Arg-His-Gly-Trp-Cys-Val-Trp-Asp-Gly-Thr-Phe-Ser (Disulfide bridge:Cys2-Cys16;Cys9-Cys21;Cys15-Cys28) |
| | PROTX I Usage And Synthesis |
| Uses | ProTx-I, a venom toxin of the tarantula Thrixopelma pruriens, is a potent, selective CaV3.1 channel blocker with IC50 values of 0.2 μM and 31.8 μM for hCaV3.1 and hCaV3.2 respectively. ProTx-I is also a potent blocker for voltage-gated Na+ channels and inhibits KV 2.1 channels[1][2]. | | References | [1] Tsuyako Ohkubo, et al. Tarantula toxin ProTx-I differentiates between human T-type voltage-gated Ca2+ Channels Cav3.1 and Cav3.2. J Pharmacol Sci. 2010;112(4):452-8. DOI:10.1254/jphs.09356fp
[2] Richard E Middleton, et al. Two tarantula peptides inhibit activation of multiple sodium channels. Biochemistry. 2002 Dec 17;41(50):14734-47. DOI:10.1021/bi026546a |
| | PROTX I Preparation Products And Raw materials |
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