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| | HOECHST 33258 Basic information |
| Product Name: | HOECHST 33258 | | Synonyms: | 2'-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE HYDRATE;BISBENZIMIDE H 33258;BISBENZIMIDE TRIHYDROCHLORIDE HYDRATE;CELLSTAIN- HOECHST 33258 SOLUTION;bisbenzimide trihydrochloride cell*culture tested;hoechst 33258 (bisbenzimide);p-(5-(5-(4-methylpiperazin-1-yl)benzimidazol-2-yl)benzimidazol-2-yl)phenol;4-(5-(4-METHYL-1-PIPERAZINYL)(2,5''-BI-1H-BENZIMIDAZOL)2''-YL)PHENOL | | CAS: | 23491-44-3 | | MF: | C25H24N6O | | MW: | 424.5 | | EINECS: | 245-689-0 | | Product Categories: | | | Mol File: | 23491-44-3.mol |  |
| | HOECHST 33258 Chemical Properties |
| Hazard Codes | Xn | | Risk Statements | 22-36/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | SM1140500 | | F | 3-8-10 | | TSCA | TSCA listed |
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ACROS
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| | HOECHST 33258 Usage And Synthesis |
| Chemical Properties | yellow solid | | Uses | Hoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution[1]. | | Definition | ChEBI: Pibenzimol is a bibenzimidazole and a N-methylpiperazine. It has a role as a fluorochrome and an anthelminthic drug. | | References | [1] Wang XJ, et al. Newly synthesized bis-benzimidazole derivatives exerting anti-tumor activity through inductionof apoptosis and autophagy. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6297-300. DOI:10.1016/j.bmcl.2012.06.102
[2] Stoli I, et al. Synthesis, DNA/RNA affinity and antitumour activity of new aromatic diamidines linked by 3,4-ethylenedioxythiophene. Eur J Med Chem. 2011 Feb;46(2):743-55. DOI:10.1016/j.ejmech.2010.12.010 |
| | HOECHST 33258 Preparation Products And Raw materials |
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