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BOC Sciences |
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16314854226 |
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Ro 04-5595 hydrochloride manufacturers
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| | Ro 04-5595 hydrochloride Basic information |
| | Ro 04-5595 hydrochloride Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble to 15 mM in water and to 100 mM in DMSO | | form | Powder |
| | Ro 04-5595 hydrochloride Usage And Synthesis |
| Uses | Ro 04-5595 Hydrochloride is a selective NMDA receptor inhibitor. | | in vivo | Ro 04-5595 hydrochloride (5-20 mg/kg, i.p.) inhibits MA-induced locomotor stimulation in mice[2].
Ro 04-5595 hydrochloride (10mg/kg, i.p., for 6 days) reduced AMPA to NMDA ratio in Cocaine self-administering rats[3].
| Animal Model: | Methamphetamine (MA) treated mice[1] | | Dosage: | 3-30 mg/kg | | Administration: | i.p., given 30min before injection of MA (2mg/kg, i.p.) | | Result: | Dose-dependently decreased MA-induced locomotor activity. |
| | IC 50 | GluN2B: 31 nM (Ki) |
| | Ro 04-5595 hydrochloride Preparation Products And Raw materials |
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