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InvivoChem |
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2091134-35-7 manufacturers
- JAK1-IN-4
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- $2800.00
-
2026-07-27
- CAS:2091134-35-7
- Purity:
- Supply Ability: 10g
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| | 2091134-35-7 Basic information |
| Product Name: | 2091134-35-7 | | Synonyms: | JAK1-IN-4;AZD4205，JAK1-IN-4;JAK1IN4,JAK-1-IN-4,JAK1 IN 4;1-Piperazineacetamide, N-[3-[5-fluoro-2-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-1H-indol-7-yl]-α,3,4-trimethyl-, (αR,3R)-;(αR,3R)-N-[3-[5-Fluoro-2-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-1H-indol-7-yl]-α,3,4-trimethyl-1-piperazineaceta mide | | CAS: | 2091134-35-7 | | MF: | C26H32FN9O2 | | MW: | 521.6 | | EINECS: | | | Product Categories: | | | Mol File: | 2091134-35-7.mol |  |
| | 2091134-35-7 Chemical Properties |
| density | 1.40±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 13.94±0.30(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | 2091134-35-7 Usage And Synthesis |
| Uses | JAK1-IN-4 is a potent and selective JAK1 inhibitor, with IC50s of 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively. JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM)[1]. | | IC 50 | JAK1: 85 nM (IC50); JAK2: 12.8 μM (IC50) | | References | [1] Annika Birgitta Margareta STRAND, et al. Compounds and methods for inhibiting jak. |
| | 2091134-35-7 Preparation Products And Raw materials |
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