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N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine manufacturers
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| | N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine Basic information |
| Product Name: | N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine | | Synonyms: | N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine;2-Thiazolamine, N-(4-fluorophenyl)-4-phenyl-;GP130 receptor agonist-1;N-(4-Fluorophenyl)-4-phenyl-2-thiazolami;N-(4-Fluorophenyl)-4-phenylthiazol-2-amine;GP130 receptor agonist-1,neuroprotective,Inhibitor,penetrant,NMDA,inhibit,GP-130 receptor agonist-1,brain,Interleukin Related,GP130 receptor agonist1,GP130,GP130 receptor agonist 1;UCLA P130 2;GP130 receptor agonist-1, 10 mM in DMSO | | CAS: | 339303-87-6 | | MF: | C15H11FN2S | | MW: | 270.32 | | EINECS: | | | Product Categories: | | | Mol File: | 339303-87-6.mol |  |
| | N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | A solid | | color | White to off-white |
| | N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine Usage And Synthesis |
| Uses | N-(4-Fluorophenyl)-4-phenyl-1,3-thiazol-2-amine is a gp130 agonist. Protects against NMDA-induced toxicity in primary hippocampal neurons in vitro. Increases STAT3 phosphorylation in SH-SY5Y cells. Brain penetrant. | | in vivo | For GP130 receptor agonist-1 (Compound 2), mice are dosed orally at 10 or 30 mg/kg, or injected subcutaneously (SQ) at 10 mg/kg, and euthanized after 1, 2, 4, 6, and 8 h post dose. At 2 h after SQ delivery at 10 mg/kg the brain Cmax is 161 ng/g while dosing at 30 mg/kg orally, results in the brain Cmax of 156 ng/g (0.57 μM). The brain to plasma ratio for 2 is ～4:1 for oral 30 mg/kg and ～7.5:1 for 10 mg/kg SQ injection[1]. | | storage | Store at +4°C |
| | N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine Preparation Products And Raw materials |
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