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| | 7BETA-HYDROXYCHOLESTEROL-25,26,26,26,27,27,27-D7 Basic information |
| Product Name: | 7BETA-HYDROXYCHOLESTEROL-25,26,26,26,27,27,27-D7 | | Synonyms: | 7BETA-HYDROXYCHOLESTEROL-25,26,26,26,27,27,27-D7;7β-Hydroxycholesterol-25,26,26,26-27,27,27-D7;(3,7)-Cholest-5-ene-3,7-diol-d7;5-Cholestene-3,7-diol-d7;7-Hydroxy Cholesterol-d7;7-Hydroxycholest-5-en-3-ol-d7;Cholest-5-ene-3,7-diol-d7;7β-hydroxy Cholesterol-d7 | | CAS: | 349553-97-5 | | MF: | C26H37D7O2 | | MW: | 395.67 | | EINECS: | | | Product Categories: | Isotope Labelled Compounds;Metabolites & Impurities;Steroids & Hormones - 13C & 2H;Intermediates & Fine Chemicals;Isotope Labeled Compounds;Pharmaceuticals;Steroids | | Mol File: | 349553-97-5.mol |  |
| | 7BETA-HYDROXYCHOLESTEROL-25,26,26,26,27,27,27-D7 Chemical Properties |
| Melting point | 174-178C | | storage temp. | -20°C Freezer | | solubility | DMF: 2 mg/ml; DMSO: 0.1 mg/ml; Ethanol: 20 mg/ml | | form | A solid | | color | White to off-white |
| Storage Class | 11 - Combustible Solids |
| | 7BETA-HYDROXYCHOLESTEROL-25,26,26,26,27,27,27-D7 Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | A labelled metabolite of Cholesterol | | Uses | Secondary metabolite of Cholesterol. A representative lot was: 84%d7; 14% d6; 1% d5 with no detectable d0. | | Biological Activity | 7β-hydroxycholesterol-d7 (7β-OHC) along with 7-ketocholesterol (7-KC) plays a key role in atherogenesis. It is distributed extensively in the arterial compartment of apo- E knockout mice. 7βOHC induces apoptosis via activation of glycogen synthase kinase-3 (GSK3). It also triggers reactive oxygen species (ROS) resulting in mitochondrial dysfunction. 7βOHC favors demyelination and is a potential oxidized oxysterol in X-linked adrenoleukodystrophy (X-ALD) disorder. |
| | 7BETA-HYDROXYCHOLESTEROL-25,26,26,26,27,27,27-D7 Preparation Products And Raw materials |
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