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| | RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT Basic information |
| | RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT Chemical Properties |
| Melting point | 220°C dec. | | storage temp. | -20°C Freezer | | solubility | Aqueous Acid (Slightly), Water (Slightly, Sonicated) | | form | Solid | | color | Off-White to Pale Beige | | Stability: | Hygroscopic |
| | RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT Usage And Synthesis |
| Description | Ribavirin 5''-monophosphate inhibits viral DNA and RNA replication in vitro via the strong competitive inhibition of inosine monophosphate dehydrogenase (IMPDH), with a reported Ki value of 270 nM, and thus inhibits guanosine triphosphate synthesis. This agent, a metabolite of the prodrug ribavirin , exhibits broad-spectrum antiviral activity, particularly against myxoviruses. The antiviral effects of ribavirin require conversion to the monophosphate form via adenosine kinase. The anti-HIV activity of ribavirin in cultured human lymphocytes, as well as the anti-influenza activity of this prodrug in MDCK cells, have been attributed to ribavirin 5''-monophosphate. | | Chemical Properties | RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT is Solid | | Uses | RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT is used as an antiviral agent | | Uses | A metabolite of Ribavirin. | | References | [1] R C WILLIS J E S D A Carson. Adenosine kinase initiates the major route of ribavirin activation in a cultured human cell line.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1978, 75 7: 3042-3044. DOI: 10.1073/pnas.75.7.3042
[2] D G STREETER. Mechanism of action of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1973, 70 4: 1174-1178. DOI: 10.1073/pnas.70.4.1174
[3] CLERCQ E D. Specific targets for antiviral drugs.[J]. Biochemical Journal, 1982, 205 1: 1-13. DOI: 10.1042/bj2050001
[4] J. BALZARINI. Mechanism of the potentiating effect of ribavirin on the activity of 2’,3’-dideoxyinosine against human immunodeficiency virus.[J]. The Journal of Biological Chemistry, 1991, 27 1: 21509-21514. DOI: 10.1016/s0021-9258(18)54668-8
[5] BROWNE M J. Mechanism and specificity of action of ribavirin.[J]. Antimicrobial Agents and Chemotherapy, 1979, 15 6: 747-753. DOI: 10.1128/aac.15.6.747 |
| | RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT Preparation Products And Raw materials |
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