| Company Name: |
BOC Sciences |
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1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
KR-32568 manufacturers
- KR-32568
-
- $98.00
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2026-07-14
- CAS:852146-73-7
- Purity: 99.91%
- Supply Ability: 10g
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| | KR-32568 Basic information |
| Product Name: | KR-32568 | | Synonyms: | 2-Furancarboxamide, N-(aminoiminomethyl)-5-(5-fluoro-2-methylphenyl)-;KR-32568 >=98% (HPLC), solid;KR 32568,KR32568;KR-32568, 10 mM in DMSO;N-Carbamimidoyl-5-(5-fluoro-2-methylphenyl)furan-2-carboxamide | | CAS: | 852146-73-7 | | MF: | C13H12FN3O2 | | MW: | 261.25 | | EINECS: | | | Product Categories: | | | Mol File: | 852146-73-7.mol |  |
| | KR-32568 Chemical Properties |
| Melting point | 176 °C | | density | 1.38±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: ~10 mg/mL | | form | solid | | pka | 7.31±0.46(Predicted) | | color | white | | InChI | 1S/C13H12FN3O2/c1-7-2-3-8(14)6-9(7)10-4-5-11(19-10)12(18)17-13(15)16/h2-6H,1H3,(H4,15,16,17,18) | | InChIKey | DTLDHYBZLVASJQ-UHFFFAOYSA-N | | SMILES | Cc1ccc(F)cc1-c2ccc(o2)C(=O)NC(N)=N |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | KR-32568 Usage And Synthesis |
| Uses | KR-32568 is a sodium/hydrogen exchanger-1 (NHE-1) inhibitor with an IC50 of 230 nM. KR-32568 has cardioprotective effects[1][2]. | | Biological Activity | Sodium/hydrogen exchanger-1 (NHE-1) inhibitor; IC50 = 0.23 μM; inhibited NHE-1-mediated rabbit platelet swelling; in anesthetized rats, reduced infarct size from 67% (control) to 43% ( at 0.1 mg/kg) and 24% ( at 1.0 mg/kg); reduced number of ventricular premature beats from 530 to 266 ( at 0.1 mg/kg) and 115 ( at 1.0 mg/kg); reduced ventricular fibrillation incidence from 17 to 8 (0.1 mg/kg) and 0 (1.0 mg/kg); implications for research and treatment of myocardial ischemic diseases. | | in vivo | KR-32568 (0.1-1.0 mg/kg; i.v.; once) exert potent cardioprotective effects in rats, such as reduces infarct size, and significantly reduces the total number of ventricular premature beats[1]. | Animal Model: | Male Sprague-Dawley rats (350-380 g) bearing 30 min ischemia/2.5 h reperfusion heart injury[1] | | Dosage: | 0.1 mg/kg and 1.0 mg/kg | | Administration: | i.v.; once | | Result: | Exerted potent cardioprotective effects in rats. |
| | References | [1] Hui-Yul Roh, et al. Cardioprotective effects of [5-(2-methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine (KR-32568) in an anesthetized rat model of ischemia and reperfusion heart injury. Pharmacology. 2005 Dec;75(1):37-44. DOI:10.1159/000086192
[2] Sunkyung Lee, et al. (5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1. J Med Chem. 2005 Apr 21;48(8):2882-91. DOI:10.1021/jm0492305 |
| | KR-32568 Preparation Products And Raw materials |
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