GW 766994

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GW 766994 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:GW 766994；GW 994
CAS:408303-43-5
Purity:98.00% Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:GW 766994
CAS:408303-43-5
Package:50mg;1560USD|100mg;2500USD|25mg;1200USD
Company Name: Aladdin Scientific
Tel:
Email: tp@aladdinsci.com
Products Intro: Product Name:GW 766994
CAS:408303-43-5
Purity:99% Package:$370.9/5mg;$590.9/10mg;$1180.9/25mg;Bulk package Remarks:99%
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:GW 766994
CAS:408303-43-5
Package:50mg;1560USD|100mg;2500USD|25mg;1200USD
Company Name: NANJING YINGWEN BIOTECHNOLOGY CO LTD
Tel: +8613382787392
Email: sales@aeechem.com
Products Intro: CAS:408303-43-5
Purity:98%

GW 766994 manufacturers

  • GW 766994
  • GW 766994 pictures
  • $1560.00 / 50mg
  • 2026-04-22
  • CAS:408303-43-5
  • Min. Order:
  • Purity: 98.77%
  • Supply Ability: 10g
  • GW 766994
  • GW 766994 pictures
  • $1560.00 / 50mg
  • 2025-07-18
  • CAS:408303-43-5
  • Min. Order:
  • Purity:
  • Supply Ability: 10g
GW 766994 Basic information
Product Name:GW 766994
Synonyms:GW 766994;GW 994;Benzamide, 4-[[[[[[(2S)-4-[(3,4-dichlorophenyl)methyl]-2-morpholinyl]methyl]amino]carbonyl]amino]methyl]-;(S)-4-((3-((4-(3,4-dichlorobenzyl)morpholin-2-yl)methyl)ureido)methyl)benzamide
CAS:408303-43-5
MF:C21H24Cl2N4O3
MW:451.35
EINECS:
Product Categories:
Mol File:408303-43-5.mol
GW 766994 Structure
GW 766994 Chemical Properties
Boiling point 685.8±55.0 °C(Predicted)
density 1.331±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:56.0(Max Conc. mg/mL);124.07(Max Conc. mM)
form A solid
pka13.40±0.46(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
GW 766994 Usage And Synthesis
DescriptionGW 766994 is an antagonist of chemokine (C-C motif) receptor 3 (CCR3) with a Ki value of 13.8 nM in an assay of eosinophil chemotaxis induced by chemokine (C-C motif) ligand 11 (CCL11). It decreases CCL11-induced cyclin-dependent kinase 5 (Cdk5) and tau phosphorylation and production of amyloid β (1-42) (Aβ42) in isolated mouse hippocampal neurons when used at a concentration of 10 μM.
UsesGW 766994 (GW 994) is an orally active and specific chemokine receptor-3 (CCR3) antagonist. GW 766994 has the potential for asthma and eosinophilic bronchitis research[1][2].
IC 50CCR3: 7.86 (pKi)
References[1] Neighbour H, et al. Safety and efficacy of an oral CCR3 antagonist in patients with asthma and eosinophilic bronchitis: a randomized, placebo-controlled clinical trial. Clin Exp Allergy. 2014 Apr;44(4):508-16. DOI:10.1111/cea.12244
[2] Zhu C, et al. Targeting CCR3 to Reduce Amyloid-β Production, Tau Hyperphosphorylation, and Synaptic Loss in a Mouse Model of Alzheimer's Disease. Mol Neurobiol. 2017 Dec;54(10):7964-7978. DOI:10.1007/s12035-016-0269-5
GW 766994 Preparation Products And Raw materials
Raw materials2-MorpholineMethanaMine, 4-[(3,4-dichlorophenyl)Methyl]-, (2S)--->4-AMINOMETHYL-BENZAMIDE
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