GW 766994 manufacturers
- GW 766994
-
- $1560.00
-
2026-07-27
- CAS:408303-43-5
- Purity: 98.77%
- Supply Ability: 10g
- GW 766994
-
- $1560.00
-
2026-07-27
- CAS:408303-43-5
- Purity: 98.77%
- Supply Ability: 10g
- GW 766994
-
- $1560.00
-
2025-07-18
- CAS:408303-43-5
- Purity:
- Supply Ability: 10g
|
| | GW 766994 Basic information |
| Product Name: | GW 766994 | | Synonyms: | GW 766994;GW 994;Benzamide, 4-[[[[[[(2S)-4-[(3,4-dichlorophenyl)methyl]-2-morpholinyl]methyl]amino]carbonyl]amino]methyl]-;(S)-4-((3-((4-(3,4-dichlorobenzyl)morpholin-2-yl)methyl)ureido)methyl)benzamide | | CAS: | 408303-43-5 | | MF: | C21H24Cl2N4O3 | | MW: | 451.35 | | EINECS: | | | Product Categories: | | | Mol File: | 408303-43-5.mol |  |
| | GW 766994 Chemical Properties |
| Boiling point | 685.8±55.0 °C(Predicted) | | density | 1.331±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:56.0(Max Conc. mg/mL);124.07(Max Conc. mM) | | form | A solid | | pka | 13.40±0.46(Predicted) | | color | Light yellow to yellow |
| | GW 766994 Usage And Synthesis |
| Description | GW 766994 is an antagonist of chemokine (C-C motif) receptor 3 (CCR3) with a Ki value of 13.8 nM in an assay of eosinophil chemotaxis induced by chemokine (C-C motif) ligand 11 (CCL11). It decreases CCL11-induced cyclin-dependent kinase 5 (Cdk5) and tau phosphorylation and production of amyloid β (1-42) (Aβ42) in isolated mouse hippocampal neurons when used at a concentration of 10 μM. | | Uses | GW 766994 (GW 994) is an orally active and specific chemokine receptor-3 (CCR3) antagonist. GW 766994 has the potential for asthma and eosinophilic bronchitis research[1][2]. | | IC 50 | CCR3: 7.86 (pKi) | | References | [1] Neighbour H, et al. Safety and efficacy of an oral CCR3 antagonist in patients with asthma and eosinophilic bronchitis: a randomized, placebo-controlled clinical trial. Clin Exp Allergy. 2014 Apr;44(4):508-16. DOI:10.1111/cea.12244
[2] Zhu C, et al. Targeting CCR3 to Reduce Amyloid-β Production, Tau Hyperphosphorylation, and Synaptic Loss in a Mouse Model of Alzheimer's Disease. Mol Neurobiol. 2017 Dec;54(10):7964-7978. DOI:10.1007/s12035-016-0269-5 |
| | GW 766994 Preparation Products And Raw materials |
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