| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
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| | HO-1-IN-1 Basic information |
| Product Name: | HO-1-IN-1 | | Synonyms: | HO-1-IN-1;HO-1 inhibitor 1;1H-Imidazole, 1-[4-(4-bromophenyl)butyl]-;Heme Oxygenase-1-IN-1;Heme Oxygenase 1 IN 1,inhibit,Inhibitor,Reactive Oxygen Species,HO-1,Heme Oxygenase1IN1;Heme Oxygenase-1-IN-1, 10 mM in DMSO | | CAS: | 1093058-52-6 | | MF: | C13H15BrN2 | | MW: | 279.18 | | EINECS: | | | Product Categories: | | | Mol File: | 1093058-52-6.mol |  |
| | HO-1-IN-1 Chemical Properties |
| Boiling point | 435.0±28.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 125 mg/mL (447.74 mM);Water : < 0.1 mg/mL (insoluble) | | form | Solid | | pka | 7.06±0.10(Predicted) | | color | White to off-white |
| | HO-1-IN-1 Usage And Synthesis |
| Uses | Heme Oxygenase-1-IN-1 (compound 2) is a potent heme oxygenase 1 (HO-1) inhibitor, with an IC50 of 0.25 μM. Heme Oxygenase-1-IN-1 can be used for cancer research[1]. | | References | [1] Floresta G, et al. Development of new HO-1 inhibitors by a thorough scaffold-hopping analysis. Bioorg Chem. 2018 Dec;81:334-339. DOI:10.1016/j.bioorg.2018.08.023
[2] Zeng X, et al. Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic polypeptide-expressing metaplasia through NLR family pyrin domain-containing 3 (NLRP3)-mediated IL-33 activation via a reactive oxygen species (ROS) -NRF2- Heme oxygenase-1(HO-1)-NF-кB axis. Free Radic Biol Med. 2023 Jun;202:46-61. DOI:10.1016/j.freeradbiomed.2023.03.024
[3] Wang X, et al. Mitochondrial GRIM-19 deficiency facilitates gastric cancer metastasis through oncogenic ROS-NRF2-HO-1 axis via a NRF2-HO-1 loop. Gastric Cancer. 2021 Jan;24(1):117-132. DOI:10.1007/s10120-020-01111-2 |
| | HO-1-IN-1 Preparation Products And Raw materials |
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