JTV-519 HEMIFUMARATE
| 中文名称 | JTV-519 HEMIFUMARATE |
|---|---|
| 中文同义词 | 化合物 T11732;化合物 JTV-519 HEMIFUMARATE;试剂JTV-519 hemifumarate (Synonyms: K201 hemifumarate);试剂JTV-519 hemifumarate (Synonyms: K201 hemifumarate);JTV-519半富马酸盐 |
| 英文名称 | JTV-519 hemifumarate |
| 英文同义词 | JTV 519 hemifumarate,JTV519 hemifumarate |
| CAS号 | 1435938-25-2 |
| 分子式 | C29H36N2O6S |
| 分子量 | 540.68 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1435938-25-2.mol |
| 结构式 |  |
JTV-519 HEMIFUMARATE 性质
| 储存条件 | -20°C, away from moisture |
|---|---|
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
JTV-519 hemifumarate (K201 hemifumarate) 是 Ca2+ 依赖性的肌质网 Ca2+ 刺激的 ATP 酶 (SERCA) 阻断剂。JTV-519 hemifumarate (K201 hemifumarate) 也是横纹肌中兰尼碱受体 (ryanodine receptors) 的部分激动剂。JTV-519 hemifumarate (K201 hemifumarate) 是一种心脏保护剂，具有抗心律失常作用。
JTV-519 (K201) inhibits inward Ca 2+ movement into large unilamellar vesicles (LUV) caused by annexin V in a dose-dependent manner. In the presence of 50 nM annexin V and 400 μM Ca 2+ , 3 μM JTV-519 shows significant inhibition of Ca 2+ movement due to annexin V, and 50% inhibition is achieved at 25 μM K201.
JTV-519 (0.5mg/kg/h, i.v., 2 h before the surgery) improves cardiac function in CLP mice, where the fractional shortening (FS) and ejection fraction (EF) are significantly increased as compared with CLP mice without JTV-519 treatment.
| Animal Model: | Wild type male C57BL/6 mice weighing 18-22g with polymicrobial sepsis produced by cecal ligation and puncture (CLP) |
| Dosage: | 0.5 mg/kg/h |
| Administration: | Applied intraperitoneally 2 h before the surgery |
| Result: | Improved cardiac function, where the EF and FS were significantly increased. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-15293B | JTV-519 HEMIFUMARATE JTV-519 hemifumarate | 1435938-25-2 | 5 mg | 750元 |
| 2026/06/05 | HY-15293B | JTV-519 HEMIFUMARATE JTV-519 hemifumarate | 1435938-25-2 | 10 mM * 1 mL in DMSO | 796元 |